Lecture 2: Cell cycle Flashcards

1
Q

G1 phase (3)

A
  • normal cellular activities
  • cell growth and duplication of organelles
  • protein synthesis
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2
Q

S phase (1)

A
  • DNA replication ; very vulnerable
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3
Q

G2 phase

A
  • synthesis of protein and microtubules
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4
Q

interphase (3)

A
  • non-dividing stage = DNA replication and growth
  • vulnerable to DNA damage during S phase
  • rapidly dividing cells especially vulnerable (skin, GI, bone marrow)
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5
Q

prophase (3)

A
  • nuclear membrane disappears
  • chromosomes condense
  • centrioles migrate to opposite poles of the cell = mitotic spindle begins to form
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6
Q

metaphase

A

paired chromosomes line up along the equator of the cell

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7
Q

anaphase

A
  • chromosomes separate and migrate to opposite poles
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8
Q

telophase (2)

A
  • nucleus divides into 2 identical cells with the same DNA composition
  • cytokinesis occurs
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9
Q

mitosis (3)

A
  • occurs in most cells of the body
  • results in 2 daughter cells containing DNA identical to parent cell
  • each has 23 pairs of chromosomes = 46 total
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10
Q

meiosis (2)

A
  • occurs in sex cells located in the gonads

- results in 4 daughter cells with 1/2 the DNA content of the parent cell = 23 chromosomes

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11
Q

specialized cells (4)

A
  • lose the ability to divide
  • red blood cells
  • neurons
  • muscle cells
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12
Q

cells that can divide by stimulus (2)

A
  • liver cells

- lymphocytes

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13
Q

cells that continuously undergo cell division (4)

A
  • high amount of S2 activity
  • skin cells
  • cells of intestinal lining
  • bone marrow cells
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14
Q

chromosome (2)

A
  • single strand of DNA and protein containing genetic info

- held together by centromere

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15
Q

chromatid

A

duplicated chromosome

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16
Q

gene

A

unit of DNA at a specific locus that provides instructions for specific protein production

17
Q

centriole (3)

A
  • organizing center for mitotic spindle composed of microtubules
  • 2 per centrisome
  • provide structural configuration and ability to separate genetic material
18
Q

karyotype (2)

A
  • # of chromosomes an individual has

- humans have 23 diploid pairs = 46 total [22 pairs autosomes, 1 sex chromosome]

19
Q

hypertrophy

A

increase in size of cells

20
Q

atrophy

A

decrease in size of cells [ex. paralysis]

21
Q

hyperplasia

A

increased mitotic activity and # of cells

22
Q

metaplasia

A

changes in cell response to disease or chronic irritation = transformation of cell into a different cell type [ex. cancer metastasis]

23
Q

neoplasm

A

new cell mass/ rapid multiplication