Lecture 2/5 1/24/25 & 2/3/25 Flashcards
What are the general characteristics of pyoderma?
-common in dogs
-rare in cats
-develops secondary to underlying disease, allergy, immunosuppression, or change in microenvironment
What typically causes pyoderma in cats?
self trauma
What are the physical barriers to infection?
-stratum corneum
-hair
What are the physiologic barriers to infection?
-cell turnover rate
-sebum
What are the immunologic barriers to infection?
-Langerhans cells
-lymphocytes
-immunoglobulins
-sweat
How does the skin flora differ between a healthy animal and an animal with pyoderma?
pyoderma has non-diverse bacteria, while healthy patients have diverse skin flora
What aspects of disease allow for pyoderma development?
-alteration of barrier function
-alteration of microenvironment
-suppression of immune system
What are the steps to bacteria causing pyoderma?
-adherence to the skin
-colonization of the skin
-invasion of abnormal skin
Which bacteria species is the primary residential on the skin?
Staphylococcus
Which bacteria can be transients on the skin?
-E. coli
-Proteus spp.
-Pseudomonas spp
-Staph.
-Strep.
-Corynebacterium spp.
What can transient bacteria do once on the skin?
-colonize abnormal skin
-become a secondary invader to Staph.
Which Staph. species are of greatest concern?
-Staph. pseudintermedius
-Staph. aureus
What are the characteristics of concerning Staph. species?
-coagulase positive
-beta-lactamase positive
What are the characteristics of methicillin resistance?
-implies resistance to drugs with beta-lactam ring structure
-altered penicillin binding protein with a poor affinity for beta-lactam antibiotics
What is multi-drug resistance?
resistance to 3 or more antibiotic classes
What is extensive drug resistance?
only 1 or 2 antibiotic classes remain that the bacteria is NOT resistant to
What are the pyoderma classifications?
-surface colonization/bacterial overgrowth
-superficial
-deep
What are the characteristics of skin fold dermatitis/intertrigo?
-skin folds are anatomic defect
-can see erythema, exudation, +/- pruritus within the folds
-can be malodorous
-must differentiate from folliculitis/furunculosis
How is surface colonization diagnosed?
-history and physical exam
-scrape
-surface cytology
What are the treatment steps for surface colonization?
-cleanse with antibacterial agents
-keep dry
-NO steroid products
-NO systemic antibiotics
-surgical revision for severe folds
What is superficial pyoderma/folliculitis?
-infection under the stratum corneum and/or within the hair follicles
-typically Staph. pseudintermedius
What are the characteristics of impetigo?
-“puppy pyoderma”/dogs < 1 year old
-occurs in non-haired areas
-can be pruritic or asymptomatic
-usually no underlying cause
-typically does not require treatment
what is the primary differential for impetigo?
Demodicosis spp.
How is impetigo diagnosed?
-physical exam
-scrape
-cytology
-response to treatment/topical antimicrobials