Lecture 2/18/25 Flashcards
Eukaryotic DNA Replication
1
Q
What are the key components of eukaryotic replication?
A
DNA polymerases (α, δ, ε), MCM helicase, RPA, PCNA, RFC, and DNA ligase.
2
Q
What is the role of DNA polymerase α?
A
It initiates DNA synthesis with primase activity.
3
Q
Which polymerase synthesizes the leading strand?
A
DNA polymerase ε.
4
Q
Which polymerase synthesizes the lagging strand?
A
DNA polymerase δ.
5
Q
What is the function of telomerase?
A
It extends the 3’ ends of chromosomes to counteract the end-replication problem.
6
Q
Which end of the chromosome does telomerase extend?
A
The 3’ end.
