Lecture 2 Flashcards
What are the 3 phases in fetal development?
Zygote, Morula, Blastocyst
The … turns into these 3 layers:
The blasocyst turns into the ectoderm, mesoderm, endoderm
Ectoderm
Skin + CN
Mesoderm
Skeleton
Endoderm
Intestines
Closure deficits of the neural tube
Anencephaly + Spina bifida
Anencephaly
Geen brein
Spina bifida
Open ruggetje
Nervous System development
- Spinal chord, brain stem
- Amygdala, cerebellum, hippocampus
- Thalamus, basal ganglia
- Cerebral cortex
Brain vesicles development
Myelencephalon, metencephalon, mesencephalon, diencephalon, telencephalon
Cell development
Profileration, migration, differentiation, selective cell death, myelinisation
Cell profileration
Making new cells/neurons
Cell migration
Moving neurons to correct position
Cell differentiation
Growing cell’s characteristics and making synaptic connections
Selective cell death
Overproduction and programmed cell death
Aptosis
Programmed cell death
Myelinisation
Myelin shealth speeds the transmissioning of neurons
Disorder in profileration effects
Microcephaly and megacephaly
Passive migration
New neurons push old neurons away towards outerlayers
Active migration
Supporting cells create route for neurons towards outerlayers
Synaptogenesis
Formation of synaptic connections
Pruning
Synapse elimination depending on experience, hormones and genes
Experience-expected synapse
Use it or lose it
Experience-dependent plasticity
Enriched environment
2 mechanisms within plasticity
Restitution & substitution
Restitution mechanism
When brain is damaged, the same brain area is fixing the damaged function
Substituition mechanism
When brain is damaged, other brain areas compensate for the damaged function
Anatomical reorganization
Other brain areas take over function
Behavioural compensation
Using aids to compensate damage, like an agenda
Crowding
Loss of function
Child neuropsychology
Study of brain-behaviour relationships in the immature, rapid developing brain
Diaschisis
Temporary disruption in development
Colleteral sprouting
Nearby functions takes over
Denervation supersensitivity
Neurons become more sensitive
Regeneration
Regrowth of fibres
Kennard Principle
If you’re going to have brain damage, have it early
Innately specialised
Specific functions belong to specific brain regions
Equipotentiality
Functions could belong to multiple brain areas
Three growth spurts
Early infancy, 7-10 years, early adolescence