lecture 18 - gut motility

Question 1

What are bulk laxatives?

Answer 1

Polysaccharide polymers that are non-absorbable in the gut

Question 2

What are osmotic laxatives?

Answer 2

Usually metal salts that aid water retention in the gut by making it osmotically difficult for the gut to absorb water

Question 3

What are stimulant laxatives?

Answer 3

Drugs that stimulate accumulation of water ad electrolytes by interacting with the enteric plexus to induce contractions, or by inhibiting intestinal cotransporters

Question 4

What are prokinetic drugs?

Answer 4

Drugs that antagonise dopamine receptors, increasing gastric emptying

Question 5

What are some of the types of anti-motility drugs?

Answer 5

Opioids, anti-cholinergics

Question 6

How do D2 receptor antagonists have an anti-emetic effect?

Answer 6

They block dopamine receptor activation in the chemoreceptor trigger zone in the brain stem

Question 7

How do H1 receptor antagonists have an anti-emetic effect?

Answer 7

They block H1 receptor activation in the vomiting zone in the brain