Lecture 17 - GPCRs Flashcards
how many TM domains
7
Nterminus extracellular to recieve ligands
4 examples of ligands
glucagon
adrenaline
dopamine
histamine
2 ways GPCRs can be inactivated
phosph
internalisation of receptor
what proteins will allow exchange of GDP for GTP after lignad binds
GEFs
what hydrolysis of GTP
the effector which acts as GAP (GTPase activated protein)
which 2 subunits are anchored in memb
alpha and gamma
what type of effector is activated by the beta-gamma subunit complex
K+ ion channels
def of secondary messengers
rapidly produced diffusable signalling molecule that activates effector protein
what allow strong activation in short time
amplication of signal
ways to terminate signal
phosph
which could trigger endocytosis of receptor = recycled OR degraded
or could be -ve feedback loop
what enzyme converts ATP to cAMP
adenylyle cyclase
what deactivates cAMP
phophodiesterase
what molecule can cAMP activate
protein kinase A
how does cAMP activate protein kinase A
removes the 2 catalytic subunits from the regulaotry subunits (which are bound by disulphide bonds)
what AAs does protein kinase A act on
serine and threonine
