3.1: Protein targetting to organelles Flashcards
1
Q
signal hypothesis
A
‘proteins have intrinsic signals that govern their transport and localization in the cell’
2
Q
what is the default destination for proteins and how many proteins remain here
A
cytosol
70%
3
Q
5 general steps for protein targetting
A
- signal - targets protein
- receptor - recognises signals
- protein loosely folded/unfolded to cross membrane
- tranlocation machinery to allow crossing of memb
- energy via ATP or GTP
4
Q
is a signal sequence for proteins part of the mature protein?
A
no, usually cleaved off
