Lecture 17

Question 1

RTK (receptor, tyrosine kinase)

Answer 1

monomer with intrinsic kinase ability, the kinase is part of the receptor

Question 2

cytokines

Answer 2

small signaling molecules, how cells communicate with each other

Question 3

hematopoietic stem cells

Answer 3

stem cells that give rise to all other blood cells

Question 4

cytokine receptors component

Answer 4

homodimers = two similar proteins || ligand binding domain and cytosolic domain

Question 5

JAK

Answer 5

tyrosine kinase that is associated with cytokine receptors

Question 6

STAT

Answer 6

transcription factor

Question 7

components of STAT

Answer 7

DNA-BD and SH2

Question 8

SH2

Answer 8

will always recognize and dock itself onto phosphorylated tyrosine residues

Question 9

two mechanisms to down regulate JAK/STAT pathways

Answer 9

phosphotyrosine phosphatase and SOCS

Question 10

Phosphotyrosine phosphatase

Answer 10

(short term) dephosphorylates and inactivates JAK, contains SH2 and phosphatase domains

Question 11

SOCS down regulation mechanism

Answer 11

(long term) has SH2 domain, binds to all phosphate groups = blockage OR can recuit E3 Ub ligase to mark receptor and JAK for proteolytic degradation

Question 12

GRB2

Answer 12

includes SH2 domain and SH3 that binds to SOS

Question 13

SOS

Answer 13

acts as GEF, activates Ras

Question 14

Ras

Answer 14

GTPase, activates Raf

Question 15

Raf

Answer 15

kinase

Question 16

MEK

Answer 16

kinase

Question 17

MAP

Answer 17

kinase, activates transcription