Lecture 16 - Urea Cycle Flashcards
What is the main function of the Urea Cycle?
to remove excess nitrogen
where in the body does the urea cycle occur?
in the liver
where does the entire urea cycle take place INSIDE THE CELL?
inside the mitochondria and the cytosol
what is the rate limiting enzyme in the urea cycle?
Carbamoyl-P-Synthetase
What can you say about the synthetase enzymes?
they cost energy — use ATP
How many nitrogen atoms are disposed by 1 urea molecule?
TWO
The urea cycle is tied to what other pathway?
gluconeogenesis
a portion of the urea cycle pathway emphasizes the transport of which 2 molecules?
aspartate and citrulline
Aspartate and Citrulline are transported from the ___ into the ____
from the MITOCHONDRIA into the CYTOSOL
Aspartate and Citrulline are condensed into ____ with the help of what enzyme?
condensed into UREA with the help of
argininosuccinate synthase
The requirement of urea synthesis is a reflection of the amount of cytosolic___________
argininosuccinate synthase
Aspartate and Citrulline must be maintained at what ratio?
1:1 ratio
Carbamoyl-P-Synthase catalyzes the conversion of ___ to ____
Bicarbonate, ammonia, and 2 ATP molecules to form carbamoyl P
In the urea cycle, several intermediates of ______ are formed
glycolsyis
Carbamoyl Phosphate is converted to…..
citrulline
Argininosuccinate could become ___ or ____
could become fumurate or arginine
When argininosuccinate becomes arginine……
some arginine is converted to urea
aspartate and citrulline are _____ of nitrogen
carrieres
