Lecture #16

Question 1

Agouti gene is also called…

Answer 1

metastable epiallele

Question 2

A^VY

Answer 2

agouti visible yellow -on = yellow = unmethylated -off = brown = methylated

Question 3

methyl donors

Answer 3

-vitamin D -folic acid -vitamin B12 -choline

Question 4

What compound is this?

Answer 4

choline -methyl donor

Question 5

imprinted allele

Answer 5

-ex: IGF2 in mammals (insulin derived growth factor) -females can silence donated male genomes coding for size to minimize risk during delivery

Question 6

CpG islands

Answer 6

cytosine-phosphate-guanine (two pairs, not one)

Question 7

CpG richness

Answer 7

25% of genome is CpG rich 70% of promoter regions are CpG rich

Question 8

nucleosome

Answer 8

8 histones in a 2x2x2 cube

Question 9

What compound is this?

Answer 9

lysine -major acetyl donator

Question 10

When the F0 gen is exposed to a toxicant, the F1 and F2 gens are also exposed. Is it heritable?

Answer 10

No. The other two generations are affected bc they were actually exposed but this change to them was not inherited bc they were there when it occurred. F3 must be affected for it to be heritable

Question 11

epigenetic level of methylation significantly reset when…

Answer 11

the organism is an embryo and when it reproduces