Lecture 15 Flashcards
1
Q
How can you determine if a drug is more soluble in oil or water?
A
1) drug deposition in fat tissues
2)passage rate through biological membranes
3)extraction of drugs
2
Q
What is the oil/water partition experiment?
A
1)add oil and water to container
2)add drug and allow system to equilibriate
3)Determine Co and Cw
4) P=Co/Cw
3
Q
meaning when P=1
A
the drug likes water and oil equally
4
Q
meaning whe P>1
A
drug is hydrohobic
5
Q
meaning when P<1
A
hydrophillic
6
Q
A
