Lecture 10-13

Question 1

WHat is the equation of pH?

Answer 1

pH= -log[H+]

Question 2

Does the pH tipically fluctuate in the body?

Answer 2

no, body fluids have well defined pH ranges and are buffered

Question 3

True or false: drug solutions should not significantly alter the pH of body fluids they contact.

Answer 3

true

Question 4

Why are drug’s pH carefully controlled?

Answer 4

ensure compatibility in body, solubility, and chemical stability

Question 5

Which functional groups have neither acidic or basic charateristics?

Answer 5

hydrocarbons, alcohols, sugars, ethers, amides, esters, ketones

Question 6

What are common acids?

Answer 6

strong- HCl, H2SO4, HNO3
weak- carboxylic acid, sulfonic acid, phenol, thiols, Imides

Question 7

How do you calculate Ka?

Answer 7

Ka=[H+][A-]/[HA]

Question 8

When determines strength of an acid?

Answer 8

functional group and its chemical enviorment

Question 9

What is a monoprotic acid?

Answer 9

can only lose 1 H atom

Question 10

What is a polyprotic acid?

Answer 10

A molecule that can lose several H atoms

Question 11

What are common bases?

Answer 11

strong-NaOH, KOH
weak-aliphatic amines, aromatic amines, guanidines

Question 11

which is a stronger base, apliphatic or aromatic amines?

Answer 11

aliphatic