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Neurobiology > Lecture 14, Serotonin > Flashcards

Lecture 14, Serotonin Flashcards

1
Q

which blood cells store serotonin?

A

platelets

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2
Q

targets of serotonin in the free blood

A

white and brown fat
liver
pancreas
muscles
macrophages

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3
Q

which enzyme converts tryptophan into 5-HTP?

A

tryptophan hydroxylase

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4
Q

how is 5HTP converted into serotonin?

A

5-HTP decarboxylase

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5
Q

which form of tryptophan is found in food?

A

L

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6
Q

serotonin is produced?

A

directly in the neuron

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7
Q

which transporter transports serotonin into vesicles?

A

VMAT2

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8
Q

how is serotonin similar to catecholamines?

A

same vesicular transporter

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9
Q

serotonin storage

A

25% ready to be released
75% stored

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10
Q

what is the role of SERT

A

actively reuptakes serotonin into pre synaptic neuron

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11
Q

VMAT2 is inhibited by?

A

reserpine/ tetrabenzine

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12
Q

which drugs cause reversal of direction of serotonin uptake transporters

A

PCA and fenfuramine

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13
Q

how does ecstasy affect SERT

A

binds to SERT and so prevents serotonin
reuptake
phosphorylates SERT to reverse direction

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14
Q

how does ecstasy cause serotonin release from vesicles into cytosol?

A

inhibition of VMAT2

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15
Q

how does ecstasy cause SERT to pump our serotonin instead of reuptaking it?

A

SERT phosphorylation

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16
Q

effect of ecstasy on serotonin, adrenergic and dopaminergic receptors

A

agonists

17
Q

ecstasy overdose

A

cardiovascular
neural
musculoskeletal
respiratory
kidney
hyperpyrexia

18
Q

what is serotonin broken down into?

A

5-HIAA

19
Q

how is the final product of serotonin catabolism excreted?

A

CSF

20
Q

which mostly enzyme catalyses the breakdown of 5HT

A

MAO-A

21
Q

why may MAO-B be present in serotonin nerve terminal

A

catabolism of other monoamines

22
Q

rostral group consists of

A

dorsal raphe and median raphe

23
Q

caudal group

A

raphe magnus and raphe pallidus

24
Q

where does the ventral rostral group send inputs to?

A

midbrain
diencephalon
basal ganglia
limbic system
cortex

25
Q

where does the dorsal rostral group send inputs to?

A

colliculi

26
Q

the dorsal and ventral rostral group merge to innervate which region?

A

the forebrain

27
Q

the spinal cord innervation from which raphe nucleus group?

A

caudal

28
Q

serotonin effect on neurons can trigger

A

depolarisaton or hyperpolarisation

29
Q

which serotonin receptors are ionic?

A

5HT3

30
Q

how many serotonin receptors are metabotropic

A

14

31
Q

Gs

A

4,6,7

32
Q

Gi

A

1,1B,1D

33
Q

Gq

A

2A,2B,2C

34
Q

which receptors are found on post/pre synaptic surface?

A

5HT1 ( inhibitory)

35
Q

which receptors are mainly on post synaptic terminal

A

5HT 2,3,4,5,6,7

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