Lecture 13, part 3: Function

Question 1

time of action for ionotropic receptors

Answer 1

ms

Question 2

time of action for metabotropic receptors

Answer 2

s/min

Question 3

how do AMPA/kainate receptors differ from NDMA

Answer 3

AMPA/kainate faster

Question 4

describe the relationship between AMPA/kainate and NMDA receptors

Answer 4

depolarisation via AMPA/kainate removes the magnesium block on NMDA

Question 5

excitatory ion channels are permeable to?

Answer 5

Na and K

Question 6

which receptor is not permeable to calcium?

Answer 6

kainate

Question 7

what does NMDA require in order to induce an inward current?

Answer 7

glycine

Question 8

explain the effect of glycine on glutamate?

Answer 8

maximises its activation of NMDAR receptor

Question 9

which receptor goes glycine only work on?

Answer 9

NMDAR

Question 10

inhibition of NMDA receptors with APV has what effect on long term potentiation

Answer 10

decreases it

Question 11

explain the role of NMDA in LTP

Answer 11

sustained depolarisation via AMPA removes magneisum block on NMDA
NMDA allows for Ca and NA outflux
Ca activates PKC
PKC amplifies effect of AMPA
PKC changes gene expression
Ca triggers NO release
NO increase cGMP levels

Question 12

how do met receptors contribute to LTP

Answer 12

ip3 and dag generation

Question 13

how is too much glutamate toxic?

Answer 13

too much calcium in cells

Question 14

what disease is glutamate implicated in?

Answer 14

epilepsy
stroke
alzheimers and parkinsons
ALS

Question 15

riluzole

Answer 15

blocks glutaminergic transmission

Question 16

calcium is released in response to

Answer 16

glutamate receptor activation
as well as calcium channels opening