Lecture 13, part 2: Receptors Flashcards
how many metabotropic glutamate receptors are there?
8
which glutamate receptors are ionotropic
AMPA, kaintate and NDMA
describe the structure of mGluRs
7 TM domains
dimers
LBD of mGluR is found in where?
extracellular matrix
which group houses mGluR1 and 5?
group 1
which group does mGluR2 and 3 belong to?
group 2
which metabotropic glutamate receptors are found within group 3?
4678
binding to metabotropic glutamate receptors 1 and 5 has what effect?
phospholipase C stimulation and PIP2 cleavage
mglur1
increase in intercellular calcium
mglur5
potassium outflux
group 2 and 3 have their effects by?
inhibiting adenylate cyclase
what effect do group 1 metabotropic receptors have postsynaptically
increase excitability via phosphorylation of different channels
what effect do group 1 metabotropic receptors have presynaptically
enhances glutamate release
what effect do groups 2 and 3 glutamate metabotropic receptors have
inhibitory
which group of glutamate receptors can also be found on gabaergic receptors
group 2
which glutamate receptors do glial cells express
5 and 3
how can the effects of an agonist on metabotropic glutamate receptors be reversed?
antagonist addition
effect of an antagonist of glutamate receptors
blocks hyperpolarisation
AMPA receptors include
A1-A4
kaintate receptors include
GluK1-Gluk5
NMDA receptors include
GLuN1, N2A,N2B,N2C,N3A,N3B
antagonist for AMPA
peramaphel
kainate antagonist
UBP-302
NDMA antagonist
Ap-5
NMDA agonists
glutamate and aspartate
NMDA is blocked by which drugs
ketmine
mg2+
pcp
mk801
nmda co-agonist
glycine
modulators of nmda receptors
magnesium and polyamines
how many subunits make up ionotropic glutamate subunits?
4
domains in each ionotropic subunit:
3 transmembrane domains and 1 membrane domain
ionic movement via ampa receptors
sodium in and potassium out
