lecture 14 - synapse stabilisation and neuronal maturation Flashcards
are synapses lost or gained during development
lost
what is polyinnervation
where each muscle fibre receives multiple inputs and each motor neuron innervates multiple fibres
what is monoinnervation
each fibre receives input from a single motor neuron
at which stage of development are muscle fibres polyinnervated
initial
why is there initially dis-coordiation of synapses
due to only 1 of 3 synapses firing at any one time
what does deliberate non-coordinated firing increase the rate of
synaptic loss
describe the ‘reward’ pathway for neurotrophins
high MMP
high BDNF
triggers synaptic potentiation through TRkb
describe the ‘punishment’ pathway for neurotrophins
low MMP
more proBDNF
axonal retraction
what does blockage of TrkB accelerate
synapse elimination
what do experiments in eyes of animals tell us about synapse stabilisation
that inputs compete for synaptic partners based on activity
why is the NMDA receptor called a coincidence receptor
it is activated in response to pre synaptic glutamate release and post synaptic action potentials
what determines neuronal maturation
transcription factors determine which genes are expressed so which set of neurotransmitters are made
how do the triceps and latissimus dorsi develop different neuronal connections in the CNS
tricep develops monosynpatic connections due to no GDNF expression
latissimus dorsi develop polysynaptic connections dues to expression of GDNF
what type of target development do mechanosensors have
inter-dependant
what are the three types of target development
dependant on inputs
independant
inter-dependant (rely on eachother)
