Lecture 13 - Cholinergic Antagonists Flashcards
What are the muscarinic antagonists? (six)
Atropine Scopolamine Glycopyrrolate Oxybutynin Ipratropium Tropicamide
What are the non-depolarizing NMJ blocking agents? (five)
D-tubocurarine Pancuronium Vecuronium Cisatracurium Atracurium
What are the depolarizing NMJ blocking agents? (one)
Succinylcholine
What does atropine come from?
Belladona/nightshade
What does scopolamine come from?
angels trumpet
What is the general distribution of atropine?
Only gets into CNS with very high doses
Mostly peripheral effects
About how long does atropine last in dogs?
30 min
What is the general distribution of scopolamine?
CNS!
What effects do you see with scopolamine?
Euphoria + Sedation + Amnesia
What determines the effects of atropine at a certain organ?
Dose
Prevailing tone
Distribution of M receptors
How do rabbits react to atropine?
Resistant, have special enzyme to metabolize quickly
How do goats, cattle, and horses react to atropine?
Can eat the plant, but injected atropine can be VERY toxic
How do swine react to atropine?
very sensitive, can’t even eat it
What are the general CNS effects of atropine?
Confusion + Coma
What are the toxic CNS effects of scopolamine?
Hallucinations + Delirium + Coma
What is the normal state of the eye?
PNS - slightly rounded lens + slightly constricted pupil
What does muscarinic antagonist do to the eye?
PNS decreased
Pupil dilated - via circular muscle
Lens flattens - via ciliary muscle
What is mydriasis?
Dilation
What is miosis?
Constriction
What side effects do you see with muscarinic blocked in the eye?
Photophobia + Blurry vision + Dry eyes
What type of muscarinic receptor is on the heart?
M2
What does M2 do at the heart?
ACh stimulates M2 on the heart at SA node
Pre-synaptic M2 decreases NE
Both decrease heart rate
What does muscarinic blockade due to the heart?
Tachycardia
When is atropine used in relation to the heart?
Cardiac arrest
What do cholinergic antagonists do to respiration?
Reverse bronchoconstriction
–or–
Bronchodilation
When is a cholinergic antagonist used in regards to respiration?
RAO or Heaves
What cholinergic antagonist is used for heaves?
Ipratropium
What does muscarinic blockade do in the GI tract?
Decrease motility + secretions
Decrease tone of bile duct