Lecture 13 Flashcards
What are the two types of neurotransmitters?
Ionotropic
Metabolic
What is ionotropic receptors?
Ligand-gated ion channels = LGIC
What are metabolic receptors?
G- protein linked receptors
What is an example of ionotropic receptor?
Skeletal muscle
Fiber muscle
What are metabolic receptor examples
Atrial muscle
Cell membrane
What are the cytoplasmic linkers for?
Sites of modulation
What are examples of alpha 7?
Limbic system
Cortex
What are examples of α3β4
PNS
What is an example of α4β2
Thalamus and cortex
True or false?
At neuronal synapses synaptic potentials are usually subthreshold and can be either excitatory or inhibitory
True
What is the result of ACh binding to the post synaptic membrane?
It causes an EPSP that decays with distance from the site of action
True or false?
nAChRs are non selective cation channels (permeable to na+, k+, ca+2)
True
What is α-BTX
Snake venom a neuro toxin
Binds competitively and irreversibly to nAChRs at neuromuscular junction causing respiratory failure and death
What type of loop is formed by a disulfide bond?
Cys loop
Where is the cys loop located?
Between two cysteine residues 13 aa apart bear N terminal
