Lecture 12A

Question 1

Antifungals disrupt ergosterol. What is ergosterol?

Answer 1

A fungi’s cell membrane

Question 2

Disease caused by fungi

Answer 2

Mycoses

Question 3

Fungal infections can either be ____ or ____

Answer 3

Localized or systemic

Question 4

Localized fungal infections

Answer 4

Aspergillosis (spores of mold), Candida (yeast), Dermatophytes (ringworm)

Question 5

Systemic fungal infections

Answer 5

Blastomycosis (soil fungus), Histoplasmosis (soil fungus- mold), Coccidioidomycosis (soil fungus), Candida, Aspergillosis

Question 6

Topical antifungals

Answer 6

Nystatin, Miconazole, Mometamax, and Tresaderm

Question 7

True or false: Ketoconazole can be used to treat Cushing’s disease in dogs, and alters cortisol levels and adrenal function

Answer 7

True

Question 8

Drug of choice for Blastomycosis

Answer 8

Itraconazole (Sporanox®️)

Question 9

Oral antifungals

Answer 9

Griseofulvin (Fulvicin®️)

Question 10

Griseofulvin is only active against ____ and ____

Answer 10

Trichophyton and Microsporum

Question 11

Systemic antifungals

Answer 11

Amphotericin B

Question 12

Systemic antifungals are used for _____

Answer 12

Serious systemic Mycoses

Question 13

What is one side affect of Amphotericin B?

Answer 13

It is very nephrotoxic