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Veterinary Pharmacology Test #2 > Lecture 10A > Flashcards

Lecture 10A Flashcards

1
Q

What are immunosuppressive drugs used to manage?

A

Immune systems that are hyperfunctioning

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2
Q

Immunosuppressive drugs work by either interfering with cell life cycles or interfering with the production of _________ and ________ _________

A

Cytokines; chemical mediators

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3
Q

What class is Prednisone/Prednisolone part of and what does it inhibit?

A

Corticosteroids; Phospholipase

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4
Q

True or false: Prednisolone is metabolized into Prednisone in the liver

A

False; Prednisone is metabolized into Prednisolone

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5
Q

Prednisone/Prednisolone is used to treat…

A

Autoimmune disease such as AIHA, Lupus, Rheumatoid arthritis, IBD, Allergies, and Atopy

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6
Q

Prednisone/Prednisolone work for ______, inhibit _____ production, inhibit _______, decrease ______ migration, and lyse/kill ________

A

Inflammation; antibody; phagocytosis; neutrophil; lymphocytes

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7
Q

The 5 P’s for side effects of Prednisone

A

Panting, polyphagia, PU, PD, pissy

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8
Q

True or false: Cyclosporine is made from a fugus

A

True

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9
Q

Cyclosporine is considered a _____ ______ _________

A

Potent systemic immunosuppressant

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10
Q

What all is Cyclosporine used to treat?

A

Kidney transplants, but most commonly KCS, and skin disorders

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11
Q

What is the trade name for Azathioprine?

A

Imuran®️

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12
Q

What is Azathioprine used to treat?

A

Suppress the immune system but also treat cancer

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13
Q

What two things does Azathioprine interfere with?

A

Nucleic acid synthesis and inhibits B and T cell division

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14
Q

What is a common side affect seen with chemotherapeutics?

A

Immunosuppression

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15
Q

True or false: Dogs are very sensitive to the immunosuppressive effects of Azathioprine

A

False; cats are

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16
Q

What is Cyclophosphamide (Cytoxan®️) used as?

A

An antineoplastic agent and immunosuppressant

17
Q

What are some side effects of Cyclophosphamide?

A

VD, BM suppression, Sterile cystitis, Alopecia

18
Q

What is the trade name for Metronidazole?

A

Flagyl®️

19
Q

What does BRM stand for?

A

Biological response modifier

20
Q

What is the purpose of immunostimulants?

A

To restore or stimulate the compromised immune response

21
Q

Tue or false: monoclonal antibodies have a direct cytotoxi effect on tumor cells

A

True

22
Q

Interferons

A

Stimulates immune system to get rid of pathogens

23
Q

What effects do interferons have?

A

Anti-tumor effects, anti-viral effects, and manipulates immune regulatory effects

Veterinary Pharmacology Test #2 (7 decks)

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