Lecture 12- Aggressive Periodontitis

Question 1

Common features of aggressive periodontitis

Answer 1

patient otherwise healthy

severe and rapid bone loss

familial aggregation

Question 2

in aggressive periodontitis, patient shouldnt have any … condition

Answer 2

systemic

Question 3

what age range is affected with LAP

Answer 3

puberty-20

Question 4

in LAP, CAL MUST affect at least one

Answer 4

1st molar

Question 5

in LAP, no more than 2 teeth are affected other than…

Answer 5

1st molars and incisors

Question 6

in LAP, CAL is inconsistent with….

Answer 6

plaque and calculus

Question 7

T/F in LAP, there is relatively more gingival inflammation

Answer 7

false

Question 8

In LAP, there is robust serum antibody response of

Answer 8

IgG2

Question 9

T/F LAP is self limiting

Answer 9

true

Question 10

age range for GAP is usually under …. but can affect older patients too

Answer 10

30

Question 11

at least ….. teeth other than 1st molars and incisors must be involved for GAP

Answer 11

3 permanent teeth

Question 12

GAP has a pronounced …. nature of destruction

Answer 12

episodic

Question 13

T/F GAP has relatively intense gingival inflammation

Answer 13

true

Question 14

T/F GAP has a poor antibody response

Answer 14

true

Question 15

which main bacteria is associated with LAP?

particularly …

Answer 15

Aa

JP2 clone, serotype b

Question 16

Aa has … which kill PMNs and macrophages

Answer 16

leukotoxins

Question 17

Aa has … which activates cells to produce PGs, IL-1b and TNF-a

Answer 17

LPS

Question 18

Aa has … which degrades collagen fibers

Answer 18

collagenases

Question 19

Aa has … and … suppressing factors

Answer 19

lymphocyte and chemotactic

Question 20

Aa can … across the JE and invade the …

Answer 20

translocate

CT

Question 21

in east asian population, which bacteria is most commonly assoc. with LAP

Answer 21

p. gingivalis

Question 22

p. gingivalis has…. like … and …

Answer 22

proteinases

gingipains

collagenases

Question 23

p. gingivalis has…. which activates cells to produce PGs, IL-1b and TNF-a

Answer 23

LPS

Question 24

p. gingivalis inhibits …. which decreases chemotaxis of PMNs

Answer 24

IL-8

Question 25

proposed inheritance mode for LAP?

Answer 25

autosomal dominant

Question 26

If you suspect AP, what is the 1st treatment principle

Answer 26

refer to periodontist

Question 27

for AP, after referral, what should be done?

Answer 27

full mouth SRP in adjunct with systemic antibiotics

Question 28

what antibiotics are common for tx of AP

Answer 28

amoxicillin+ metronidazole

ciprofloxacin+ metronidazole

Question 29

what steps are needed after full mouth SRP + antibiotics ?

Answer 29

possibly periodontal surgery

meticulous periodontal supportive therapy