Lecture 12 Flashcards
0
Q
Metastasis kills patients __% of the time?
A
90%
1
Q
Micrometasteses are smaller than __
A
2mm
2
Q
What % of circulating tumor cells successfully initiate a metastatic focus?
A
Less than 0.01%
3
Q
What helps cancer cells invade tissues by cutting BM and ECM?
A
Matrix metalloproteinases (MMPs)
4
Q
What metal ion is required for MMPs’ catalytic activities?
A
Zinc
5
Q
What is the rate limiting step of metastasis?
A
Colonization
