Lecture 11: Stress & Cardiovascular Diseases Flashcards
chronic risk factors for cardiovascular disease
age, cigarette smoking, diabetes
acute risk factors for cardiovascular disease
hemodynamic and vasoconstrictive factors
Mittleman et al. (1995)
examined how anger can be a stimulus for acute myocardial infarction
- found that when people experienced anger two hours before the heart attack, the risk of the actual heart attack was twice as high
- appears stress is involved in a heart attack
cardiovascular system
consists of the heart and blood vessels
the heart
a muscle that pumps five liters of blood through the body every minute
- left ventricle: pumps blood thoughout the body
- right ventricle: pumps blood throughout the lungs (does not have to work as hard)
- blood is pumped from the aorta through the body
blood vessels
ensure that all tissue can be supplied with oxygen and nutrients
veins
the blood vessels that carry the blood back to the heart
systemic circulation
the major system delivering oxygenated blood to tissues and organs
- blood circulation: from the left ventricle to the aorta, the arteries, then the tissues
- blood gets deoxygenated in the tissues, then flows through the veins to the right atrium
pulmonary circulation
the system responsible for oxygenating blood
- deoxygenated blood flows from the right atrium to the right ventricle of the heart into the pulmonary arteries, which then carry the deoxygenated blood into the lungs, releasing carbon dioxide and picking up oxygen
- the now oxygenated blood returns to the left atrium, and the systemic circulation starts again
coronary arteries
supply the heart muscle (myocardium) itself with oxygenated blood, enabling its proper contraction and function
- if the coronary arteries become narrowed, the heart does not receive enough blood, causing part of the heart muscle to die (heart attack)
pressure gradient
indicates the change in pressure in blood vessels
- 2 types of blood pressure can be distinguished
diastolic blood pressure/under pressure
when the heart relaxes
systolic blood pressure/overpressure
when the heart contracts
electrocardiogram
measures changes in the electrical charge of extracellular fluid due to electrical changes that occur in all cardiac muscle cells combined
coronary artery disease
the narrowing or blocking of coronary arteries which supply blood to the myocardium
- happens through the process of accumulating fatty acids like cholesterol and calcium on the inner walls of the arteries (atherosclerosis)
- leads to the formation of plaques that narrow and harden the arteries, restricting blood flow to the heart
coronary heart disease
damage to the heart muscle itself
- can be caused by not getting enough oxygen or nutrients due to reduced blood flow from the coronary arteries (atherosclerosis)
- might further present as angina (chest pain), myocardial infarction, or ischemia