Lecture 11 - Schizophrenia & Psychotic Disorders Flashcards
At what age is schizophrenia usually diagnosed?
Men: 18-25
Women: 25-35
Males are more likely to develop it.
What is late onset schizophrenia?
Diagnosis of schizophrenia after age of 45 - characterized by increased positive symptoms
–> Women disproportionately affected (perhaps d/t protective factor of estrogen)
What are the four major dopamine reliant pathways in the brain and what are their roles?
Mesocortical tract
–> Cognition, motivation, emotional responses
mesolimbic
–> Associated with reward and desire
Nigrostriatal
–> movement initiation
tuberoinfundibular tracts
–> Linked to pituitary and hormonal release of FSH, TSH, LH, and prolactin
What are the four phases of schizophrenia development?
1 - Premorbid
2 - Prodromal
3 - Acute
4 - Residual
What is waxy flexibility?
When a person appears catatonic but can be passively moved
What are two common affective changes in schizophrenia?
Lability and incongruence
What is a state of psychosis?
A state in which the individual is experiencing positive symptoms
–> Hallucinations, delusions, or disorganized thoughts, speech, or beheaviour
What are the three phases of the acute phase of schizophrenia?
Acute psychosis
Stabilization
Maintenance & Recovery
What occurs during the acute psychosis phase of acute schizophrenia?
What are the therapeutic goals during this time?
Abrupt onset of positive symptoms following prodromal phase - perhaps due to overcompensation for loss of dopamine, especially in mesolimbic tract
–> Disruptive to social functioning
–> Often coupled with substance use
–> Risk of harm to self/others
Therapeutic Goals: Ensure safety Alleviate positive symptoms, normalize sleep and intake, address substance use.
What occurs during the stabilization phase of acute schizophrenia?
What are the therapeutic goals during this time?
Establish a diagnosis, symptoms may be mostly negative and less acute. Substance use is eliminated/reduced.
Requires an adjustment period for families and patients.
Socialization with others and recovery begins
Therapeutic Goals:
Stabilization of symptoms is focus - may use LAI
Psychosocial education starts
What occurs during the maintenance and recovery phase of acute schizophrenia?
What are the therapeutic goals during this time?
Schizophrenia a a chronic illness, recovery includes periods of symptom exacerbation
Therapeutic Goals:
Medication adherence is priority
Stress management - stress can lead to decompensation
Continued education for patient and family
How is recovery time from a psychotic episode affected by previous relapses?
With each relapse, there is a longer recovery time
–> For this reason, early diagnosis and treatment is very important
What factors can encourage recovery in the maintenance and recovery phase of acute schizophrenia?
Early Detection with short duration of untreated psychosis
Optimal treatment which includes not just medications, but also social support network, a stable living environment, access to meaningful activity and companionship, attention to physical health, and use of CBT or other psychotherapy
What should should the focus be during CBT for those with schizophrenia?
Address cognitive distortions related to living with auditory hallucinations and delusional content
What are the different types of schizophrenia?
Paranoid, disorganized, catatonic, undifferentiated, residual type
What comorbidities are commonly seen in schizophrenia?
There is an association between diabetes and schizophrenia medications - metabolic syndrome
Disordered water/electrolyte imbalances d/t excessive drinking
Substance use + Cigarette smoking
Depression
Milieu therapy for schizophrenia should be focused on what?
Social functioning to provide security and dignity through structure
Behavioural therapy with which focus can be helpful for people with disorganized schizophrenia?
Reinforcing certain desired behaviours can be helpful for disorganized patterns
What should we focus on during an interpersonal functioning assessment with schizophrenia?
Social isolation, emotional detachment, appearance, self-esteem
What is echopraxia?
Repeating other’s movements
What are the six priorities of physiological nursing interventions with schizophrenia?
- Promotion of self-care activities
- Develop routine for hygiene activities (help with motivation and execution)
- Activity, exercise, nutrition
- Appetite increases with 2nd gen antipsychotics, help with food choices
- Thermoregulation
- Promotion of normal fluid intake
What is the most important psychoeducation factor with schizophrenia?
The ability to identify s/s of decompensation and create a relapse prevention plan
Therapeutic effects of antipsychotics may take how long? How long is an adequate trial time?
Therapeutic effects may take 1-2 weeks
–> Adequate trial period is 6-12 weeks
–> use PRN medications might be necessary during acute phase
Consider need for LAI and identify interventions for antipsychotic side effects.
What differentiates typical and atypical antipsychotics
First gen binds in a much stronger way to receptors and have more significant EPS
Second gen are more effective at improving negative symptoms but have increased risk of metabolic syndrome
What antipsychotic has an increased risk of increasing prolactin secretion from the anterior pituitary grand?
Risperidone
What are the EPS symptoms?
Dystonia
–> Involuntary spasms (esp in head + neck)
Akathisia
–> Inability to sit still, increased distress
Pseudoparkinsonism (Dyskinesias)
–> Rigidity, slowed movements, tremor. Can be observed as the loss of spontaneous movements such as arm swing with gait.
What is tardive dyskinesia?
A late-appearing chronic extrapyramidal side effect of antipsychotics.
Characterized by repetitive involuntary movements of the face/head, neck/trunk, and limbs.
It is typically irreversible