Lecture 11: Integraton Of Metaboliism Flashcards

1
Q

T/F: The liver processes most, but not all, dietary amino acids.

A

True

  • The kidney can process some as well
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2
Q

T/F: The presence of glucose-6-phosphatase makes the liver uniquely able to release glucose from glycogen into the bloodstream

A

True

  • The muscles can do this only in a limited capacity
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3
Q

T/F: the liver synthesizes most of the urea produced in the body

A

True

  • The kidney can do this as well
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4
Q

T/F: The liver normally fuels the body by releasing its fat stores during fasting

A

False

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5
Q

T/F: one of the livers major jobs is to provide fuels for the brain

A

True

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6
Q

What 3 things can glucose-6-phosphate make?

A

Glycogen
Pyruvate
Ribose-5-P

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7
Q

What 4 things can pyruvate make?

A

Acetyl CoA
Lactate
Alanine
Oxaloacetate

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8
Q

What is the role of the portal vein?

A

To carry nutrients from intestine to liver

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9
Q

What is the role of the lymphatic system in metabolism?

A

Carries lipids from intestine to liver

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10
Q

What is the role of adipose tissue in metabolism?

A

Synthesizes, stores and mobilizes TAGs

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11
Q

At what low blood sugar level can you start to see subtle neurological signs, hunger, sweating and trembling

A

~60

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12
Q

At what low blood sugar level does lethargy, convulsions and coma occur?

A

<40

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13
Q

What pathways are turned on in a well fed liver?

A
Glycolysis
FA synthesis
TAG synthesis 
Glycogenesis
Cholesterol synthesis
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14
Q

What pathways are on in well-fed adipose tissue?

A

Glycolysis
FA synthesis
TAG synthesis
Cholesterol synthesis

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15
Q

What pathways are on in a well fed muscle?

A

Glycogenesis

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16
Q

What pathways are on in a fasting liver?

A

Glycogenolysis
GLuconeogenesis
FA oxidation
Ketone body synthesis

17
Q

What pathways are turned on in fasting adipose tissue?

A

FA oxidation
TAG breakdown

no glucose uptake

18
Q

What pathways are on in a fasting muscle?

A

FA oxidation
Ketone body utilization

** no glucose uptake**

Remember muscle doesnt have glucagon receptors so it would only be responding to epinephrne