lecture 11 ACH, epi, DA

Question 1

Ach is synthesized by

Answer 1

Choline acetyltransferase from actyl coA, and choline

Question 2

Ach is broken down by

Answer 2

Acetylcholinesterase into choline and acetate(to the astrocyte)

Question 3

Acetylcholine receoptos

Answer 3

Nicotinic : ionotropic

Muscarinic receptors

Question 4

Nicotinic are found mainly at

Answer 4

neuromuscular junctions

Question 5

_ molecuces of Ach have to bind to Nicotinic receptors to activate ___

Answer 5

2, ion gated channels

Question 6

mACh receptors: metabotropic

Answer 6

Muscarinic receptors

M1-M5

Question 7

ACh-Muscarinic Antagonist is it fast or slow

Answer 7

Atropine , slow

Question 8

M4 and M2 are G_

Answer 8

Gi

Question 9

M1, M3, M5 are G_

Answer 9

Gq (phospolipase c is effected)

Question 10

Ach ___ heart rate while Norepinephrine/Epinephrine __

Answer 10

slows, increase

Question 11

Ach ___ eye muscle while atropine ____ the muscle

Answer 11

constricts, dilates

Question 12

all Catecholamine Receptors are _________ and can be

Answer 12

All Metabotrobic, excitation or inhibitory

Question 13

all receptors are _____ not ______

Answer 13

selective not specifics

Question 14

Norepinephrine/Epinephrine receptors

Answer 14

alpha 1-2 and beta 1-4

Question 15

dopamine is transported into the presynaptic cell

Answer 15

by dopamine transporters, Reuptake and metabolized by postsynaptic cell

Question 16

dopamine is primary located in

Answer 16

Substantia nigra

Ventral Tegmental Area (VTA)

Question 17

D2 family receptors are

Answer 17

Gi inhibitory

Question 18

D1 family receptors are

Answer 18

Gs excitatiory

Question 19

Role for DA in the Peripheral Nervous System

Answer 19

Circulating and locally formed dopamine

Question 20

Norepinepherine is primarily located in

Answer 20

Locus coeruleus and has wide spread effects

Question 21

Norepinepherine receptors functions

Answer 21

attention/ wakefulness

Question 22

Norepinepherine is made from dopamine in

Answer 22

synaptic vesicles

Question 23

Norepinepherine is mainly inactivated by

Answer 23

reuptake into the postsynaptic cell

Question 24

Norepinepherine produced primarily by the \_\_\_\_\_ cells of the 
 \_\_\_\_\_\_ \_\_\_\_\_(gland) and is secreted into the

Answer 24

chromaffin, adrenal medulla, blood stream

Question 25

Norepinephrine/Epinephrine can actiave what types of metabotropic receptors

Answer 25

all of them, Gs. Gq, and Gi

Question 26

acleerator nerve ( sympathetic nervous system _____ heart rate

Answer 26

increases , NE/Epi

Question 27

vegas nerve, parasympathetic nervous system _____ heart rate

Answer 27

decreases heart rate (Ach)