lecture 11

Question 1

Ach is broken down or retaken uo tinto the cleft

Answer 1

broken down

Question 2

monoamines are typically inactivaed by

Answer 2

removal by

Question 3

Neurotransmitter criteria

Answer 3

synthesis
Localization
release 
inactivation
pharmocology

Question 4

Neurotransmitter criteria Synthesis: the molecule is synthesized in the

Answer 4

presynaptic neurons

Question 5

Neurotransmitter criteria Localization: the molecule is present in the

Answer 5

presynaptic neurons

Question 6

Neurotransmitter criteria Release: the molecule is released upon

Answer 6

stimulation of the presynaptic neuron

Question 7

Neurotransmitter criteria inactivation

Answer 7

a specific mechanism or a set thereof exists to remove the molecule from the synaptic cleft or to degrade it

Question 8

Neurotransmitter criteria Pharmacology: when applied exogenously (e.g., from a micropipette), in concentrations similar to those observed following stimulation of the presynaptic cell, the molecule

Answer 8

agonist) mimics the action of the endogenously released transmitter; Antagonists will block effect.

Question 9

Neurotransmitter deff

Answer 9

Chemical that allow the movement of information from one neuron to an adjacent neuron.

Question 10

types of neurotransmitters amino acids

Answer 10

GABA (i), Gylcine(i), Glutamate(e)

Question 11

types of neurotransmitters Biogenic Amines (5)

Answer 11

Serotonin, Dopamine, Norepinephrine, Epinephrine, Histamine

Question 12

types of neurotransmitters Purines

Answer 12

Adenosine, ATP

Question 13

types of neurotransmitters Peptide

Answer 13

Neuropeptide Y, Substance P, Enkephalin etc

large

Question 14

channel linked_____

G protein ______

Answer 14

ionotropic, metaotropic

Question 15

the __ subunit binds to the effector protein, what source of enery does this come from in metobotropic receptors

Answer 15

alpha, (GDP->GTP), GTP is bound to alpha

Question 16

what subunits activate ion channels

Answer 16

beta and gamma

Question 17

when a ligand binds to a g protein receptor what is the first step

Answer 17

the alpha beta gamma subunits bind

Question 18

where is calcium sequesteded

Answer 18

in the ER or mitocondria (which can also release it)

Question 19

how is calcium removed

Answer 19

na/ca pump, in ER ca pump, mitocondria