Lecture 11 Flashcards
1
Q
What is the difference between Mendelian and Multifactorial diseases?
A
Mendelian - Single gene causes the disease
Multifactorial - risk factors with intermediate penetrance , multiple genes and environmental risk factors
2
Q
What are the 3 reasons for low penetrance?
A
Interaction with other loci, interaction with environment, Chance
3
Q
What does the genomic diagnosis determine?
A
The treatment method.
4
Q
Whats the best way to investigate complex diseases?
A
Case control association studies. Compare genotypes between individuals affected with disease and those with no evidence of disease
