Lecture 10: Mescorticolimbic system 1: Reward Aversion

Question 1

the ventral midbrain

Answer 1

a key hub regulating the functions of the limbic system

Question 2

the nucleus accumbens is located in the ventral part of the striatum and is divided into 2 parts

Answer 2

shell and core

nucleus accumbens contains 90-95% of Gabergic neurons (MSNs)

Question 3

Medium Spine Neurons are divided into 2 major neuronal populations

Answer 3

D1= excitatory
D2= inhibitory

D2 receptors have a higher affinity for Dopamine than D1 receptor

Question 4

The binding of dopamine to BLANK facilitates avoidance/aversion-related behaviors

Answer 4

D2

Question 5

The release of Dopamine and its binding to BLANK receptors facilitate reward-related behaviors

Answer 5

D1

Question 6

VTA-DA neurons projecting into the Nac encode

Answer 6

reward responses

Question 7

VTA-DA neurons projecting into the mPFC encode

Answer 7

aversive responses

Question 8

Lateral Habenula

Answer 8

A key hub controlling the activity of VTA DA neurons that project to mPFC