Emotions II- Agression and Stress Flashcards
Aggression
a motivated innate behavior that is expressed in different manners(physical, verbal)
Aggressive behavior
an associated symptom of many psychiatric disorders and can manifest thorughout the life span, from ADHD in children adolescents, to domestic violence in adults, to dementia in older adults
Agressive behavior usually manifests under circumstances of :
i. Mating
ii. Defend territory
iii. Self-defense
iv. Hunt
Urbach-Wiethe disease
individuals are impaired to detect angry facial expressions(fearless patients)
The BNST is considered an extension of the amygdala and has extensive connections with
-Limbic regions (amygdala, hypothalamus, hippocampus, etc)
-striatal regions(nucleus accumbent)
-VTA
-Prefrontal regions
The VMH has 2 major distinct neuronal types
- Neurons that express the nuclear co-receptor
- Neurons that express the estrogen receptor
Optogenetic activation of VMH-alpha-SF-1 Neurons triggers
defensive behaviors
Optogenetic activation of VMH-aEsr-1 Neurons triggers
aggressive behaviors in mice
Estrogen has two main receptors
alpha
beta
estrogen binding to Alpha receptors
mediate aggression
estrogen binding to Beta receptors
reduce aggression
estrogen combined with progesterone
faciliate aggression behavior, however, progesterone alone reduces aggression and also anxiety