Lecture #10 Flashcards
Fc gamma RI
On macrophages, neutrophils, dendritic cells and eosinophils
Phagocytosis and activation
Fc gamma RIIA
On macrophages, neutrophils, eosinophils and platelets
Phagocytosis and degranulation
Fc gamma RIIB
On B cells
Negative feedback
Fc gamma RIIIA
On NKC
Activation
Fc epsilon RI
On mast cells, basophils and eosinophils
Degranulation
What is the time required for sensitization in allergic reactions?
14 days
In the activation of mast cells upon second exposure to an allergan how many receptors should be cativated?
At least 2
What are the first line of molecules secreted from mast cells upon activation?
Preformed granules with:
Histamine, heparin, serotonin, tryptase, chimase, carboxypeptidase
What are the second line of molecules secreted from mast cells upon activation?
PLA releases AA and activating COX, LOX:
PGD2, LTC4, LTD4, LTE4, PAF
What are the third line of molecules secreted from mast cells upon activation?
Activation of cytokine gene expression (2-4h)
IL3, IL4, IL5, IL6, TNFalpha
Upon allergan binding to an IgE on a mast cell intracellular _________ motif activates signal transduction pathway
ITAM
Explain the “late phase reaction” events during allergic reaction
Delayed secretion of IL5 from mast cells along with IL5 secretion from Th2 will activate eosinophils degranulation (occurs about 8h after the first phase reaction)
2 types of mast cells
Mucosal- react to inhaed or ingested allergan
Connective tissue- reat to skin or intravenous allergan
What are the main symptoms of anaphylactic shock?
- Increased HR
- Increased vascular permeability
- Hypotension and decreased tissue perfusion
- Broncospasm
- Respiratory or circulatory collapse
- Death
In which cases can anaphylactic shock occur?
- Intra venous allregan (animal toxin/ drug)
2. Quick absorbtion through the gut mucosa to the blood (peanut)
