Lecture 10

Question 1

Sleep and gene expression

Answer 1

Delaying sleep by 4 hours for 3 days decreased circadian gene expression sixfold

Question 2

Sleep across the lifespan

Answer 2

Reduces TST and reduced contribution of REM
Adolescence - changes to actual slow waves (delta power, amplitude)
New borns - quiet (NREM little movement), active (REM movement)

Question 3

Primary and secondary consciousness

Answer 3

Primary - relates to simple awareness that includes perception and emotion
Secondary - depends on language and includes such features as self reflective awareness, abstract thinking, volition and meta-cognition

Question 4

Two models of consciousness

Answer 4

Level and content
- degree of wakefulness vs subjective experience inclu sensations, emotions, feelings
AIM
Activation (brain energy level)
Input-output gating (access to sensory info)
Modulation (status of neuromodulatory chemicals

Question 5

Sleep and epilepsy

Answer 5

Generalised spike wave discharges are generated by pathological use of the thalamocortical networks
SD increases likelihood of seizures

Question 6

Proposal of hibernation and increased SWA

Answer 6

SWA did the maintenance of synaptic strengths