Lecture 10 Flashcards
negative control
-default “ON”
-if proteins that regulate the expression of the gene are removed – the
gene would be expressed.
repressor in negative control
A protein that binds the transcription start site of a negatively controlled gene
induction in negative control
loss of repression
positive control
default of “OFF”
-if proteins that regulate the expression of the gene are removed – the gene would NOT be expressed.
Regulating proteins can…
regulate more than one gene or operon
diauxic growth
two different growth rates due to exclusive use of one, then the other food source in order of priority
global control systems
regulate expression of many different genes simultaneously
catabolite repression
an example of global control that ensures that the best carbon and energy source is used first; causes diauxic growth
In catabolite repression, ___________ is controlled by an ______ protein and is a form of _______ control
transcription, activator, positive
cyclic AMP receptor protein (CRP)
activator protein
cyclic AMP
key molecule in many metabolic control systems; derived from a nuclei acid precursor and is a regulatory nucleotide
Archaea uses _____________ to control transcription
DNa-binding proteins
NrpR
example of an archaea repressor protein from methanococcus maripaludis that represses genes involved in nitrogen metabolism
Prokaryotes regulate cellular metabolism in response to..
environmental fluctuations
signal transduction
external signal is detected by sensor and transmitted to regulatory machinery
