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Precision Cancer Medicine > Lecture 1 - Intro > Flashcards

Lecture 1 - Intro Flashcards

1
Q

What is precision cancer medicine?

A

Use molecular data and traditional clinical information to tailor medicine to provide most benefit and minimize risks

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2
Q

5 properties of cancer cells:

A 
Loss of Contact inhibition
increased GF secretion
increased oncogene expression
Loss of tumour suppressor genes
Neovascularisation
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3
Q

10 Hallmarks of cancer

A 
Sustaining proliferative signalling
Evading growth suppressors
Avoiding immune destruction
Enabling replicative immortality
tumour promoting inflammation
activating invasion and metastases
Inducing angiogenesis
Genome instability and mutation
Resisting cell death
Deregulating cellular energetics
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4
Q

5 types of chemo drugs

A

Alkalyting and platinum agents
antimetabolites
Intercalating agents
Spindle poisons

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5
Q

What do alkalyting and platinum agents target?

A

DNA

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6
Q

What to antimetabolites target?

A

DNA synthesis

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7
Q

What are nitrogen mustards?

A

Alkalyting

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8
Q

What is methotrexate?

A

Antimetabolite

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9
Q

What is doxorubicine?

A

intercalating

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10
Q

vinblastine

A

spindle poisons

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11
Q

4 clinical endpoints:

A

Complete remission
partial remission
stable disease
disease progression

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12
Q

How to target sustained proliferative signalling?

A

EGFR inhibitors

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13
Q

How to target evading growth suppressors?

A

Cyclin dep kindase inhib

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14
Q

Target avoiding immune destruction

A

anti-CTLA4 mAb

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15
Q

Target enabling replicative immortality

A

telomerase inhibitors

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16
Q

target tumour promoting inflammation

A

anti-inflammatory

17
Q

target evasion and metastasis

A

HGF/c-Met inhibitors

18
Q

target induction of angiogenesis

A

anti VEGF

19
Q

Target genome instability and mutation

A

PARP inhibitors

20
Q

Target resistance of cell death

A

proapoptotic BH3 mimetics

21
Q

Target deregulation of energetics

A

aerobic glycolysis inhibitors

22
Q

two types of biomarkers

A

correlative and functional

23
Q

7 uses for biomarkers

A 
risk assessment
diagnostic
prognostic
predictive
pharmacodynamic
treatment response
recurrence

Precision Cancer Medicine (10 decks)

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