Antibody Drug Conjugates

Question 1

3 modes of drug binding to DNA

Answer 1

Intercalation
Covalent binding
Minor groove binding

Question 2

2 ways of covalent binding

Answer 2

Alkylation and coordination

Question 3

3 examples of alkalyting agents

Answer 3

Nitrogen mustards
Chloroethylbitrosoureas
Mitomycin C

Question 4

2 examples of coordination

Answer 4

Cisplatin

Carboplatin

Question 5

2 examples of intercalating agents

Answer 5

Doxorubicin

Daunorubicin

Question 6

1 example of strand breaking agent

Answer 6

Bleomycin

Question 7

4 ways alkalyting agents bind

Answer 7

Monoadduct
Intrastrand crosslink
Interstrand crosslink
DNA protein cross link

Question 8

3 components of Ab drug conjugated

Answer 8

Ab, linker, drug

Question 9

Property that Ab should have in Ab drug conjugate

Answer 9

High tumour specificity
High acidity
High ag expression

Question 10

3 properties that a linker must have

Answer 10

Stable in vivo circulation
Cleaved inside target fell
Stable upon storage

Question 11

3 properties that a drug in Ab drug conjugate must have

Answer 11

High potency
Linkeable
Water soluble