Lecture 1 - GIT Structure and Function Flashcards

1
Q

What are the jobs of the GIT (7)

A

Motility
Secretion
Digestion
Absorption
Communication
Immune system
Detoxification/modification via metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is secreted by the GIT

A

Electrolytes, water, digestive enzymes, bile salts, acid, base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why is GIT motility important

A

Mixes digesta to be maximally exposed to epithelial cells
Moves digesta down GIT with muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does GIT breakdown do

A

Breakdown foods into simpler chemical compounds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does GIT absorption do

A

Transfer nutrients to circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Role of GIT communication

A

With the nervous system, endocrine system, etc
Full? Hungry? Nauseous?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the major components of the GI tract

A

Mouth, pharynx, esophagus, forestomach (ruminants), stomach, small intestine, cecum & large intestine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the sections of the forestomach

A

Rumen, reticulum, omasum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Parts of the small intestine

A

Duodenum -> jejunum -> ileum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Major players of a birds GIT

A

Crop -> pro-ventriculus -> gizzard -> SI -> LI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How does body size affect transit time in fully mature dogs

A

Once GIT fully mature, transit time is similar despite size differences in breeds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The esophagus has stratified squamous intestinal arrangement… why?

A

Many layers because we are not trying to absorb anything, but they need to be protective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The mucosa layer contains

A

The epithelial cell layer
Connective tissue
Lamina propria
Muscle layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Four different microscopic layers of the small intestine

A

Mucosa
Submucosa
Muscularis externa
Serosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The muscularis externa includes what kinds of muscle.

A

Circular muscle, longitudinal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The serosa includes…

A

Connective tissue
Periotneum

17
Q

Lamina propria is includes..

A

Capillaries, nerve fibers, smooth muscle, immune cells, arteriole, venuole, lymphatic

18
Q

The submucosa contains…

A

Nerves, glands (if present)

19
Q

What are the types of epithelial cells**

A

Columnar absorptive cells
Mucous (goblet) cells
Enteroendocrine cells
Paneth cells
Intestinal stem cells

20
Q

What do enteroendocrine and paneth cells do

A

Enteroendocrine = releases hormones into blood circulation to communicate locally and systemically

Paneth = secrete antimicrobial molecules to provide host defense against gut

21
Q

Which type of cell gives rise to the other types of epithelial cells

A

Intestinal stem cells

22
Q

How often do cells replace

A

Every 3-5 days

23
Q

What happens to the villi of germ free cells

A

They elongate, have narrow lamina properia

24
Q

Where do cells replicate? Which cells replicate?

A

Intestinal stem cells replicate in the crypt

25
Q

Why do SI epithelial cells have a lot of mitochondria/rough endoplasmic reticulum?

A

Mitochondria bc they need a lot of ATP
RER because they produce a lot of proteins

26
Q

What keeps harmful agents out of absorption

A

Tight junctions between cells

27
Q

What proteins form a tight junction

A

Occludin, claudin, zona occludin

28
Q

What damages tight junctions causing impairment

A

Inflammatory cytokines
Reactive oxygens
Pathogenic bacteria
Stress

29
Q

Microvilli increase…

A

Surface area/absorptive surface

30
Q

What kind of intestinal arrangement does the esophagus have

A

Stratified squamous