Lecture 1 Flashcards
What is human physiology?
Study of the functional organization of the human body
What is homeostasis?
It is the condition in which the body’s internal environment remains relatively constant within limits.
* Contains optimum concentrations of gases, nutrients, ions and water. Optimal temperature and pressure
What are the three basic components of a homeostatic control pathway?
- Sensory components (receptor protein)
- Integrator (neural circuits)
- Effector component ( ion pump or excretory organ)
What is stress in regards to homeostasis?
Any stimulus that creates an imbalance in the internal environment.
What cation is most abundant in the intracellular fluid?
potassium
What cation is most abundant in the exracellular fluid?
sodium
What anion is most abundant in the extraacellular fluid?
chloride
What is the definition of a feedback system?
Circular situation in which the information about the status of something is continually reported to a central control region.
What is a negative feedback loop and its characteristics?
A change in some parameter that causes a response that results in a return of that parameter to normal baseline. The response reverses the direction of the initial condition. Characteristics: diminishes the original change, stabilizing
What is a positive feedback loop and its characteristics?
A change in some parameter that causes a response to continue. It intensifies the stimulus. Characteristics: enhances the original change, destabilizing and can lead to runaway effects.
What is gain?
is the degree of effectiveness with which a control system maintains constant conditions.
Gain=correction/error
What is the structure of a cell membrane?
A phospholipid bilayer with cholesterol inserted among the phospholipids. Proteins are associated with the membrane
What is an integral protein?
Are either inserted into the membrane on one side or the other or pass all the way through and are exposed on either side of the membrane.
What is a peripheral protein?
Are loosely attached to one surface of the membrane or the other and are easily removed.
Many peripheral proteins are attached to the membrane by what?
GPI-anchored proteins