Lecture 1 Flashcards
Epidermis Renewal
Biweekly by maturation and exfoliation. Fed from the dermis and subcutaneous circulation. Denucleation occurs.
Dermis Renewal
Actively metabolizing tissue retains structure. Elastic fibers. Does not de-nucleate and exfoliate.
Elastic fibers in dermis
elastin, collagens, GAGs (clycosaminoglycans/mucopolysaccharides)
Epidermal cells
continually replicating and maturing into the cornified protective stratum corneum layer
Dermal fibroblast cells
responsible for production and homeostasis of the underlying structural later of skin by synthesis and excretion of fibrillar proteins
Melanocytes
production and transport of melanin inter- and intracellularly
Langerhans cells
dendritic immunologic actors
Hair follicle
produces complex hair structure in an orderly cycle from epidermal cells
Sebaceous gland
holocrine excretory gland producing sebum for hair and skin lubrication. Exits into hair shaft.
Eccrine sweat glands
secretory bodies that act to control internal temperature by secreting water while maintaining electrolyte balance.
Apocrine glands
associated with hair follicles; secretes milky fluid which contains proteins and lipid. May have pheromonal function, impacts body odor.
Nerve receptors
tactile, temperature, pressure, stimulus response.
Merkel’s disk
touch, pressure (static)
Meissner’s corpuscule
touch, pressure (dynamic)
Ruffini Ending
stretching of skin
Pacinian corpuscule
deep pressure, vibration (dynamic)
Krause end bulb
Thermoreceptor
Tan
increased production of melanosomes to melanocytes
Production of dermis
fibroblasts
Skin physiology
Processing of xenobiotics, immunological responses, and radiation responses
Skin pharmacology activity
antioxidants, anti-inflammatory, enzyme modulation, immune enhancement
Lipophilic zone
stratum corneum, viable epidermis. As SC keratonizes, it becomes more lipophilic to keep water in and toxins out
Hydrophilic zone
dermis
Routes of skin penetration
transfollicular, direct transdermal (Most common), via eccrine gland
