Lecture 1 Flashcards
1
Q
Describe cocaine in the 19th century (4)
A
- uncontrolled
- available from grocery stores
- mechanism not understood
- included in patent medicines
2
Q
Who were Bier and Hildebrandt/what did they do?
A
Bier theorized that “cocainisation of the spinal cord” might allow surgery without general anaesthesia
They performed six surgeries injecting cocaine into themselves
3
Q
What went wrong with Bier and HIldebrandt’s experiments?
A
Bier lost CSF as the needle and syringe didn’t match (wasn’t standardized then)
4
Q
What did Paul Ehrlich do? (4)
A
- researched sleeping sickness
- tested >900 arsenical compounds
- 1909 #606 tested on syphilis
- released 1910: salvarsan
5
Q
Define pharmacology
A
Actions of drugs on living organisms
6
Q
Define pharmacokinetics
A
Handling of drug by body
7
Q
Define pharmacodynamics
A
Mechanisms of drug action
