ELM 2.2

Question 1

Which of the following bond types will normally be the weakest?

Answer 1

VDW forces

Question 2

Which atom can act as a good hydrogen bond donor and a good hydrogen bond acceptor in biological molecules?

Answer 2

Nitrogen

Question 3

What is the requirement for being a hydrogen bond acceptor and donor?

Answer 3

the requirement for being a hydrogen bond acceptor is to be electronegative and to have lone pairs of electrons. To be an donor, the atom must be electronegative and bonded to hydrogen. Only nitrogen meets these criteria

Question 4

What is the maximum bond strength of a hydrogen bond in biological molecules?

Answer 4

20-30 kJ/mol

Question 5

An alpha helix is an example of what level of protein structure?

Answer 5

secondary
- Primary structure is the amino acid sequence, secondary is the folding into discrete patterns like alpha helices and beta sheets. Tertiary is the folding pattern of a subunit and quaternary is when multiple discrete proteins come together

Question 6

An example of a drug that covalently modifies its target is:

Answer 6

Aspirin acting at cyclo-oxygenase : Aspirin “kills” COX by covalently modifying it. This mechanism is key to aspirin being used to prevent strokes and heart attacks