Lect 18 Cell Cycle, Apoptosis, Cancer

Question 1

Proto-oncogenes & Cause
1. 
2.
3.
4.

Answer 1

1. RAS (gly –> val) = lots of cancers
2. EGF = glioblastoma
3. ABL = chrom 9/22 translocation; chronic myeloid lukemia (CML)
4. Her2 (val –> glutamine) = breast cancer

Question 2

Tumor Suppressor Genes & Cause
1.
2.
3.
4.

Answer 2

1. p53 = lots of cancers
2. RB = retinoblastoma
3. APC = colon cancer (Beta-catenin mutation)
4. BRCA1 = breast cancer

Question 3

p53 mutations can cause _______ Syndrome and ______ ______.

Two carcinogens that mutate p53 are _______ from cigarette smoke and ______, a fungal metabolite

Answer 3

Li-Fraumeni Syndrome and Ataxia Telangiectasia

Benzopyrene from cigarette smoke

Aflatoxin, a fungal metabolite

Question 4

Neurofibromatosis is caused by mutation in NF-1 gene, encoding for ___, which typically deactivates ___

Answer 4

GAP, which typically deactivates RAS