Lect 11-12 DNA Rep/repair/transcription

Question 1

Xeroderma Pigmentosum is caused by inability to repair _____ ______ after exposure to UV light, which is done by the ______ _____ Repair mechanism

Answer 1

Prymidine dimers

Nucleotide Excision Repair

Question 2

Hereditary nonpolyposis colorectal cancer is caused by inability of ______ Repair mechanism

Answer 2

Mismatch Repair

Question 3

Breast cancer is often associated with the _____ gene, which is fixed by _____ Repair mechanism that fixes double strand breaks (NHEJ)

Answer 3

BRCA1/2 gene

Recombination Repair

Question 4

Transcription Sequence:

_____ binds TATA box, then _____ is recruited, followed by _____, ___ ___, _____, and _____

Answer 4

TFIID, then TFIIB, followed by TFIIF, RNA Pol 2, TFIIE, and TFIIH

DBFEH = “debfeh”

Question 5

_____ removes histones on chromatin by ______, which opens up DNA for transcription

Answer 5

HATs

acetylation opens DNA

Question 6

Fragile X Mental Retardation (FMR1) gene involves what problem

Answer 6

CGG seq gets over-copied upstream into promoter region, and silenced due to CYTOSINE METHYLATION

Question 7

Ascorbic acid (____ __) is essential for the enzymes _____ and _____ ______, which involve the crosslinking of _____

Answer 7

Vitamin C

lysyl and prolyl hydroxlyases

crosslink collagen

Question 8

Dyskeratosis congenital disease is caused by a mutant _______ ___ gene, which makes them die of progressive _____ _____ failure

Answer 8

telomerase RNA gene

Bone marrow failure