LEC4A. Cells Flashcards
the cell is the basic unit of structure & function because it demonstrates all qualities of life processes
it is the simplest collection of matter that can live
Cell
Father of Microscopy
Anton van Leeuwenhook (1632)
Who invented lens
Zaccharias & Hans Janssen (1590)
He discovered cells (Micrographia)
Robert Hooke (1665)
German botanist and co-founder of the cell theory
“All plants are made of cells.”
Matthias Jakob Schleiden (1839)
a German zoologist and co-founder of the cell theory
“All animals are made of cells.”
Theodor Schwann (1839)
a German physician and co-founder of the cell theory
proposed biogenesis stated that all living cells arise from pre-existing living cells, that there is no spontaneous creation of cells from nonliving matter.
Rudolf Virchow (1858)
Classic Cell Theory (3)
- All living things are made up of one or more cells.
- Cells are the basic unit of life.
- All cells arise from pre-existing cells
Modern Cell Theory (6)
- Cells make up all life.
- Cells are functional and structural units.
- Cells are formed by division.
- Cells contain hereditary information.
- Cells are chemically the same
- Energy flow occurs within cells
Cell Wall Functions
- protects the plant cells,
- maintain its shape &
- prevents excessive uptake of water
Present both in plant and animal cell
Covers and protect the cell
Facilitate substance transport
Maintain the shape of the cell
Cell Membrane
Present both in plant and animal cell
Contains the endomembrane system that regulates protein traffic & performs metabolic functions
Protoplasm
Information or Control Center of the cell
Houses the genetic information
NUCLEUS
2 parts of nucleus
- Nuclear Envelope -2 layers with pore complexes
- Chromosomes – discrete unit of DNA
Biosynthetic Highway
Transports protein to other parts of the cell
ENDOPLASMIC RETICULUM
2 types of Endoplasmic Reticulum
- Smooth ER – synthesize lipids, store Ca+ & detoxify poison
- Rough ER – make secretory protein, membrane factory &
synthesize phospholipid
Shipping & Receiving Center
Modifies & packages proteins
GOLGI APPARATUS
Powerhouse
For cellular respiration that produces ATP
MITOCHONDRIA
Protein Factory
Synthesizes proteins
RIBOSOMES
2 types of ribosomes
- Free Ribosomes – suspended in the cytoplasm
- Bound Ribosomes – attached to ER & n. envelope
Digestive Compartment
Contains hydrolytic enzyme that digests excess or worn out organelles
a. Autodigestion – cell destruction
b. Phagocytosis –phagein (to eat) & kytos (vessel)
c. Autophagy – cell repair
LYSOSOMES
Oxidation
Converts fatty acids to smaller substances & produces hydrogen peroxide (H2O2) as a by-product
PEROXISOME
Responsible for cell motility, maintain shape, gives support and regulate biochemical activities
CYTOSKELETON
3 types of Cytoskeleton
- Microtubules
- Intermediate Filament
- Microfilament
Capture Light Energy
Contain the green pigment, chlorophyll, that captures light necessary for photosynthesis
CHLOROPLASTS
Green pigment in plants
Contents of Chloroplasts
- thylakoids → membranous system in the form of flattened, interconnected sacs
- granum → stacks of thylakoid
- stroma → fluid outside the thylakoids
Diverse Membrane Compartment
Holds organic and inorganic compounds
VACUOLES
3 Types of vacuoles
- Food vacuoles → formed by phagocytosis
- Contractile vacuoles → pumps excess water out of the cell
- Central vacuoles (Plant Cells only) → its membrane is selective in transporting solutes
Essential for the proper functioning of cells and tissues. They help to maintain the integrity of the tissues, to anchor the cells together, and to allow the cells to communicate with each other.
INTERCELLULAR JUNCTIONS
4 Types of Intercellular functions
- Tight junctions
- Adherens junctions
- Desmosomes
- Gap junctions
2 types of cells
- Prokaryotic cells
- Eukaryotic cells
Differences between prokaryotic and eukaryotic cells
- Prokaryotic cells do not have a nucleus. Eukaryotic cells have a nucleus.
- Prokaryotic cells do not have membrane-bound organelles. Eukaryotic cells have membrane-bound organelles
- Prokaryotic cells are typically much smaller than eukaryotic cells.
- The DNA in prokaryotic cells is circular, while the DNA in eukaryotic cells is linear.
- Prokaryotic cells have a single chromosome, while eukaryotic cells have multiple chromosomes.
In prokaryotes, these are DNA molecules containing the organism’s genome.
In eukaryotes, these are DNA molecule complexed with RNA and proteins to form a threadlike structure containing genetic information arranged in a linear sequence.
Chromosomes
two main sections of a chromosome
Arm
two identical copies of a chromosome that are joined together at the centromere.
Sister chromatids
constricted region of the chromosome that joins the two sister chromatids together.
Centromere
protein complex that helps to keep the two sister chromatids together.
Cohesin
4 Locations of Centromere
- Metacentric Chromosomes
- Submetacentric Chromosomes
- Acrocentric Chromosomes
- Telocentric Chromosomes
It has a centromere in the center, such that both sections are EQUAL LENGTH
Metacentric Chromosomes
It has a centromere SLIGHTLY OFFSET from the center leading to a slight asymmetry in the length of the two sections
Submetacentric Chromosomes
It has a centromere which is SEVERELY OFFSET from the center leading to one very long and one very short section.
Acrocentric Chromosomes
It has a centromere at the very end of the chromosome.
Telocentric Chromosomes
The Cell Cycle (4)
- G1 Phase (first gap)
- S Phase (synthesis)
- G2 Phase (2nd gap)
- M Phase (mitosis)
The time it takes for a cell to complete one cycle of growth and division. How many hours is cell growth?
4-6 hours
Chromosomes are duplicated in how many hours?
10-12 hours
How many hours cell growth occurs in preparation for cell division?
5-6 hours
Division of nucleus to form 2 genetically identical daughter nucleus with diploid number of chromosomes
Mitosis
The Key Roles of Cell Division (3)
- For unicellular organisms’ reproduction = binary fission
- For multicellular organisms to grow & develop
- For cell renewal and repair
__________ is the longest phase of the cell cycle, and it is divided into three stages: G1, S, and G2.
Interphase
What happens during Interphase? (4)
- Centrioles duplicate
- Nuclear envelope is intact
- Nucleus still present
- Chromosomes duplicate
4 phases of mitosis
- Prophase
- Metaphase
- Anaphase
- Telophase
First phase of mitosis. Chromosome condensation, nuclear envelope breakdown, formation of the mitotic spindle
Prophase
- Centrioles move to opposite poles & form mitotic spindle
- Nucleolus absent
- Chromosomes condense & form sister chromatids
- Nuclear envelope starts to fragment
PROPHASE
- Kinetochore microtubules attach at the kinetochore
- Nuclear envelope is absent
- Sister chromatids align at metaphase plate
- Centrioles at opposite poles
METAPHASE
- Kinetochore microtubules pull chromosome strands to the opposite poles
- Cohesion dissolved causing sister chromatids to part
ANAPHASE
- Nucleolus reforming
- Cytokinesis
- Nuclear envelope starts to form
- Chromosomes less dense
TELOPHASE
Chromosomes line up at the equator of the cell, mitotic spindle is fully formed
Metaphase
Centromeres of the chromosomes split, sister chromatids are pulled apart by the mitotic spindle
Anaphase
Chromosomes arrive at opposite poles of the cell, nuclear envelope reforms, cytoplasm divides
Division of the nucleus to form 4 genetically unidentical daughter nucleus with haploid number of chromosomes
Meiosis
Separates homologous chromosomes
Meiosis I
Separates sister chromatids
Meiosis II
__________ is the first and longest stage of meiosis
Prophase 1
Sub-stages of Meiosis (5)
- Leptotene
- Zygotene
- Pachytene
- Diplotene
- Diakinesis
- Centrioles move to opposite poles & form meiotic spindle
- Nucleolus absent
- Chromosomes condense. Synapsis occurs. Crossing-Over occurs
- Nuclear envelope starts to fragment
Formation of homologous chromosomes (homologs)
Synapsis
Exchange of DNA Segments among homologs
Crossing-Over
Chromosomes appeared w/in the nuclear envelope but are NOT yet fully condensed.
The chromosomes start to condense and become visible.
Leptotene
Synapsis occurs wherein homologs begin to unite by coming into approximate alignment. Once the homolog pairs synapse they are called tetrads (Gk. Tetra = four) or bivalents.
Homologous chromosomes pair up and form synaptonemal complexes.
Zygotene
2 sister chromatids of each chromosome separate from each other making them look thicker. Crossing-over occurs wherein non-sister chromatids exchange DNA between them.
Crossing over occurs between non-sister chromatids of homologous chromosomes.
Pachytene
Fused non-sister chromatids begin to separate from each other by the movement of the chiasma (pl. chiasmata) toward the ends of the chromatids. This process of sliding toward the ends is known as terminalization.
The synaptonemal complexes break down, but the homologous chromosomes remain attached at chiasmata.
Diplotene
Chromosomes line up at the equator of the cell, mitotic spindle is fully formed
Metaphase
Centromeres of the chromosomes split, sister chromatids are pulled apart by the mitotic spindle
Anaphase
Chromosomes arrive at opposite poles of the cell, nuclear envelope reforms, cytoplasm divides
- Centrioles move to opposite poles & form meiotic spindle
- Nucleolus absent
- Chromosomes condense. Synapsis occurs. Crossing-Over occurs
- Nuclear envelope starts to fragment
Formation of homologous chromosomes (homologs)
Synapsis
Exchange of DNA Segments among homologs
Crossing-Over
Fused non-sister chromatids begin to separate from each other by the movement of the chiasma (pl. chiasmata) toward the ends of the chromatids. This process of sliding toward the ends is known as terminalization.
The synaptonemal complexes break down, but the homologous chromosomes remain attached at chiasmata.
The point of contact between two homologous chromosomes during prophase I of meiosis.
chiasma (plural chiasmata)
The chromosomes continue to condense, and the nuclear envelope breaks down
Diakinesis
- Centrioles at opposite poles
- Nuclear envelope is absent
- Homologs align at metaphase plate
- Kinetochore microtubules attach at the kinetochore
METAPHASE 1 & 2
- Kinetochore microtubules pull chromosome strands to the opposite poles
- Synaptonemal complex dissolved causing homologs to part
ANAPHASE 1 & 2
- Nucleolus reforming
- Nuclear envelope starts to form
- Cytokinesis begins
- Chromosomes less dense
TELOPHASE 1 & 2
Chromosomes line up at the equator of the cell, mitotic spindle is fully formed
Metaphase
Centromeres of the chromosomes split, sister chromatids are pulled apart by the mitotic spindle
Anaphase
Chromosomes arrive at opposite poles of the cell, nuclear envelope reforms, cytoplasm divides
Formation of homologous chromosomes (homologs)
Synapsis
What happens during PROPHASE 1? (4)
- Centrioles move to opposite poles & form meiotic spindle
- Nucleolus absent
- Chromosomes condense. Synapsis occurs. Crossing-Over occurs
- Nuclear envelope starts to fragment
Exchange of DNA Segments among homologs
Crossing-Over
division of the nucleus
karyokinesis
division of the cytoplasm
Cytokinesis
Chromosomes arrive at opposite poles of the cell, nuclear envelope reforms, cytoplasm divides
Telophase
What happens during PROPHASE 1? (4)
- Centrioles move to opposite poles & form meiotic spindle
- Nucleolus absent
- Chromosomes condense. Synapsis occurs. Crossing-Over occurs
- Nuclear envelope starts to fragment
Exchange of DNA Segments among homologs
Crossing-Over
Chromosomes line up at the equator of the cell, mitotic spindle is fully formed
Metaphase
Formation of homologous chromosomes (homologs)
Synapsis
Centromeres of the chromosomes split, sister chromatids are pulled apart by the mitotic spindle
Anaphase
Chromosomes arrive at opposite poles of the cell, nuclear envelope reforms, cytoplasm divides
Telophase
Chromosomes line up at the equator of the cell, mitotic spindle is fully formed
Metaphase
Formation of homologous chromosomes (homologs)
Synapsis
- Centrioles move to opposite poles & form meiotic spindle
- Nucleolus absent
- Chromosomes condense. Synapsis occurs. Crossing-Over occurs
- Nuclear envelope starts to fragment
PROPHASE 1 & 2
Centromeres of the chromosomes split, sister chromatids are pulled apart by the mitotic spindle
Anaphase
Exchange of DNA Segments among homologs
Crossing-Over
__________ is the process by which haploid spermatozoa (sperm cells) develop from germ cells in the seminiferous tubules of the testes.
Spermatogenesis
__________ is the process by which haploid ova (egg cells) develop from oogonia in the ovaries of female mammals.
Oogenesis
Three Events Unique to Meiosis
- Synapsis & Crossing Over
- Homologs on the Metaphase Plate
- Separation of Homologs
Chromosomes line up at the equator of the cell, mitotic spindle is fully formed
Metaphase
Centromeres of the chromosomes split, sister chromatids are pulled apart by the mitotic spindle
Anaphase
Chromosomes arrive at opposite poles of the cell, nuclear envelope reforms, cytoplasm divides
Telophase
- Centrioles move to opposite poles & form meiotic spindle
- Nucleolus absent
- Chromosomes condense. Synapsis occurs. Crossing-Over occurs
- Nuclear envelope starts to fragment
PROPHASE 1 & 2
Formation of homologous chromosomes (homologs)
Synapsis
Exchange of DNA Segments among homologs
Crossing-Over