[LEC] Unit 8: DNA Viruses Flashcards
DNA Enveloped Virus
Hepadnaviridae
Herpesviridae
Poxviridae
DNA Naked Virus
Parvoviridae
Papillomaviridae
Polyomaviridae
Adenoviridae
Anelloviridae
Genus of Hepatitis B virus
Orthohepadnavirus
Virion of Hepa B
DANE Particle
T or F: Hepadnaviridae is under the classification of double stranded DNA with single stranded region
T
Australian Antigen
HBsAg
Only marker not found in the serum, only in liver biopsy
HBcAg
Components of the core antigen
HBeAg
6 HBV serological markers
HBsAg
Anti-HBs
Anti-HBc IgM
Anti-HBc
HBeAg
Anti-HBe
T or F: If you are positive in Anti-HBsAg, it means that you
have a current/present or chronic infection
F
HBsAg
This HBV marker indicates recovery or immunity; gained after vaccination
Anti-HBs
HBV marker present in acute infection (<6 months)
Anti-HBc IgM
This HBV marker indicates previous or ongoing infection
Anti-HBc
Best HBV marker during the window period
HBcAg
This marker indicates that the virus is replicating ir is in high levels
HBeAg
This HBV marker indicates indicates lower level of HBV
Anti-HBe
T or F: Herpesviridae is double stranded
T
Causes lytic and latent infections
Herpesviridae
Herpesviridae remain in
WBC and peripheral nerves
Genus of HSV 1 and HSV 2
Simplexvirus
Diseases caused by Herpes-Simplex Virus 1
Oral Herpes – Gingivostomatitis
HSV Encephalitis (Adult)
Ocular Herpes – Keratoconjunctivitis
Diseases caused by Herpes-Simplex Virus 2
Genital Herpes
Neonatal Herpes
HSV Encephalitis (Neonates)
T or F: Chickenpox is under HHV3
T
Genus of VZV
Varicellovirus
Recurrent form of chickenpox
Shingles
Large, rounded keratinocyte with a hypertrophic nucleus, hazy or absent nucleoli, and abundant basophilic cytoplasm; associated with chickenpox
Tzanck Smear
Genus of EBV
Lymphocryptovirus
Disease caused by EBV
Infectious Mononucleosis (Kissing disease)
T or F: EBV produces tumors
T
Associated with Burkitt’s Lymphoma and other B-cell Lymphoma
Epstein-Barr Virus
Primary targets of EBV
B Lymphocytes / B cells
Receptor of the virus on the B cell
CD21
Lab. diagnoses for EBV
Hematology and Immunology
In a hematology di erential smear for EBV, we can detect the
presence of
Atypical lymphocytes
nonspecific antibodies; screening test
Heterophile Antibody test
confirmatory test for EBV
EBV Specific Antibody Test
Test wherein:
IgG positive means you’ve had or currently have the infection; IgM positive means the infection has been reactivated.
EBV-VCA IgG/IgM (viral capsid antigen)
EBV test wherein a positive test result is usually associated with past infection.
EBV-EBNA IgG (nuclear antigen)
EBV test wherein a positive test may mean you have an active or reactivated infection
EBV-EA-D IgG (early antigen)
EBV Specific Antibody Test (5)
Anti-VCA
Anti-EA IgG
Anti-EA/D
Anti-EA/R
Anti-EBNA
Formerly “Salivary gland” virus
Cytomegalovirus
Similar to mononucleosis (In terms of pathology)
Cytomegalovirus
Cytomegalovirus remains latent in
WBC
endothelial cells
Microscopic characteristic of Cytomegalovirus
Owl’s eye appearance
T or F: Most children demonstrate antibody against cytomegalovirus
F
Adults
Genus of HHV 6 and 7
Roseolovirus
Diseases caused by HHV 6
Exanthem subitum/ Roseola infantum/ 6th disease
Cells targeted by HHV 6
T cells
The most common cause of rashes in children
German measles (Rubella)
Genus of HHV 8
Rhadinovirus
Disease caused by HHV 8
Kaposi sarcoma
T or F: As a double stranded DNA virus, Poxviridae replicates in the nucleus
F
cytoplasm
Largest and most complex virus
brick or ovoid in shape
Poxviridae
T or F: Poxviridae produces skin lesions
T
Orthopox is the genus for
Variola
Vaccinia
Cowpox virus
Monkeypox virus
Smallpox is caused by
Variola
First virus to be eradicated
Smallpox
T or F: Vaccinia virus is pathogenic to man
F
He developed the vaccine for the Variola virus using the Vaccinia virus/antigen, leading to the eradication of smallpox.
Edward Jenner
Edward Jenner used the principle of
cross-reactivity
Genus of Molluscum contagiosum virus
Molluscipoxvirus
Small pink warts (benign tumors in skin) are caused by
Molluscum Contagiosum
T or F: Molluscum contagiosum is transmitted via fomites
T
Zoonotic infection among cows
Cowpox virus
Prevalent in small communities in Europe
Cowpox virus
Zoonotic infection (monkeys, rodents)
Monkeypox virus
Monkeypox virus caused small outbreak in US (2003) – ______ rats from pet store
Gambian
Genus of ORF virus
Parapoxvirus
Zoonotic infection (goats, sheep)
ORF Virus
Caused by ORF
contagiosum pustular dermatitis
Single stranded linear DNA
Parvoviridae
2 types of parvoviridae
defective and non-defective
T or F: In the defective type of parvoviridae, there is a problem with the virus, which requires another virus for replication.
T
Disease caused by B19 virus
Erythema infectiosum (5th disease) or 5th disease
T or F: B19 virus was the only member of Polyomaviridae until 2005
F
Parvoviridae
Causative agent of 1st Disease
Rubeola virus (Measles)
Genus of HBoV
Bocavirus
causes a variety of upper and lower respiratory tract illness
Human Bocavirus
Causes warts, tumors, and condylomas in man
Papillomaviridae
HPV causes
Condyloma acuminate
Most common STD
HPV
Very common and typically asymptomatic in most human populations studied
Polyomaviridae
Genus of Polyomavirus except Merkell Cell Virus
Polyomavirus
*Merkell - Orthopolyomavirus
First isolated in urine of immunosuppressed kidney
tissue transplant patient
Named after initials of a Sudanese patient
BK Virus / HPV 1
First isolated from patient with progressive
multifocal encephalopathy
Causes disease in AIDS px
JC Virus / John Cunningham virus / HPV 2
Discovered in 2007 in samples of human respiratory secretions
KI Virus / HPV 4
WU Virus / HPV 5
KI virus is named after
Karolinska Institute
WU Virus is named after
Washington University
One of the 7 human oncoviruses
Merkell Cell Virus
of polyomavirus strains
14
Double stranded linear DNA
Adenoviridae
Number of adenoviridae serotypes
51
Genus of Adenovirus
Mastadenovirus
Causes common cold and URT diseases like pharyngitis, conjunctivitis, and pneumonia
cancer in animals
Adenovirus
Single stranded DNA positive sense
Newly discovered genus
Anelloviridae
Ring / circular genome
Anelloviridae
Genus of TTV
Alphatorquevirus
Reported in Japanese patient in 1997
TTV
T or F: Transfusion Transmitted virus is extremely common even in healthy individuals
T
Other name for Transfusion Transmitted Virus
Torque Teno Virus