[LEC] Unit 8: DNA Viruses Flashcards by kehliess dumdum

DNA Enveloped Virus

Hepadnaviridae
Herpesviridae
Poxviridae

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DNA Naked Virus

Parvoviridae
Papillomaviridae
Polyomaviridae
Adenoviridae
Anelloviridae

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Genus of Hepatitis B virus

Orthohepadnavirus

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Virion of Hepa B

DANE Particle

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T or F: Hepadnaviridae is under the classification of double stranded DNA with single stranded region

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Australian Antigen

HBsAg

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Only marker not found in the serum, only in liver biopsy

HBcAg

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Components of the core antigen

HBeAg

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6 HBV serological markers

HBsAg
Anti-HBs
Anti-HBc IgM
Anti-HBc
HBeAg
Anti-HBe

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T or F: If you are positive in Anti-HBsAg, it means that you
have a current/present or chronic infection

HBsAg

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This HBV marker indicates recovery or immunity; gained after vaccination

Anti-HBs

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HBV marker present in acute infection (<6 months)

Anti-HBc IgM

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This HBV marker indicates previous or ongoing infection

Anti-HBc

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Best HBV marker during the window period

HBcAg

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This marker indicates that the virus is replicating ir is in high levels

HBeAg

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This HBV marker indicates indicates lower level of HBV

Anti-HBe

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T or F: Herpesviridae is double stranded

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Causes lytic and latent infections

Herpesviridae

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Herpesviridae remain in

WBC and peripheral nerves

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Genus of HSV 1 and HSV 2

Simplexvirus

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Diseases caused by Herpes-Simplex Virus 1

Oral Herpes – Gingivostomatitis
HSV Encephalitis (Adult)
Ocular Herpes – Keratoconjunctivitis

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Diseases caused by Herpes-Simplex Virus 2

Genital Herpes
Neonatal Herpes
HSV Encephalitis (Neonates)

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T or F: Chickenpox is under HHV3

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Genus of VZV

Varicellovirus

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Recurrent form of chickenpox

Shingles

Large, rounded keratinocyte with a hypertrophic nucleus, hazy or absent nucleoli, and abundant basophilic cytoplasm; associated with chickenpox

Tzanck Smear

Genus of EBV

Lymphocryptovirus

Disease caused by EBV

Infectious Mononucleosis (Kissing disease)

T or F: EBV produces tumors

Associated with Burkitt’s Lymphoma and other B-cell Lymphoma

Epstein-Barr Virus

Primary targets of EBV

B Lymphocytes / B cells

Receptor of the virus on the B cell

CD21

Lab. diagnoses for EBV

Hematology and Immunology

In a hematology dierential smear for EBV, we can detect the presence of

Atypical lymphocytes

nonspecific antibodies; screening test

Heterophile Antibody test

confirmatory test for EBV

EBV Specific Antibody Test

Test wherein: IgG positive means you've had or currently have the infection; IgM positive means the infection has been reactivated.

EBV-VCA IgG/IgM (viral capsid antigen)

EBV test wherein a positive test result is usually associated with past infection.

EBV-EBNA IgG (nuclear antigen)

EBV test wherein a positive test may mean you have an active or reactivated infection

EBV-EA-D IgG (early antigen)

EBV Specific Antibody Test (5)

Anti-VCA Anti-EA IgG Anti-EA/D Anti-EA/R Anti-EBNA

Formerly “Salivary gland” virus

Cytomegalovirus

Similar to mononucleosis (In terms of pathology)

Cytomegalovirus

Cytomegalovirus remains latent in

WBC endothelial cells

Microscopic characteristic of Cytomegalovirus

Owl’s eye appearance

T or F: Most children demonstrate antibody against cytomegalovirus

F Adults

Genus of HHV 6 and 7

Roseolovirus

Diseases caused by HHV 6

Exanthem subitum/ Roseola infantum/ 6th disease

Cells targeted by HHV 6

T cells

The most common cause of rashes in children

German measles (Rubella)

Genus of HHV 8

Rhadinovirus

Disease caused by HHV 8

Kaposi sarcoma

T or F: As a double stranded DNA virus, Poxviridae replicates in the nucleus

F cytoplasm

Largest and most complex virus brick or ovoid in shape

Poxviridae

T or F: Poxviridae produces skin lesions

Orthopox is the genus for

Variola Vaccinia Cowpox virus Monkeypox virus

Smallpox is caused by

Variola

First virus to be eradicated

Smallpox

T or F: Vaccinia virus is pathogenic to man

He developed the vaccine for the Variola virus using the Vaccinia virus/antigen, leading to the eradication of smallpox.

Edward Jenner

Edward Jenner used the principle of

cross-reactivity

Genus of Molluscum contagiosum virus

Molluscipoxvirus

Small pink warts (benign tumors in skin) are caused by

Molluscum Contagiosum

T or F: Molluscum contagiosum is transmitted via fomites

Zoonotic infection among cows

Cowpox virus

Prevalent in small communities in Europe

Cowpox virus

Zoonotic infection (monkeys, rodents)

Monkeypox virus

Monkeypox virus caused small outbreak in US (2003) – ______ rats from pet store

Gambian

Genus of ORF virus

Parapoxvirus

Zoonotic infection (goats, sheep)

ORF Virus

Caused by ORF

contagiosum pustular dermatitis

Single stranded linear DNA

Parvoviridae

2 types of parvoviridae

defective and non-defective

T or F: In the defective type of parvoviridae, there is a problem with the virus, which requires another virus for replication.

Disease caused by B19 virus

Erythema infectiosum (5th disease) or 5th disease

T or F: B19 virus was the only member of Polyomaviridae until 2005

F Parvoviridae

Causative agent of 1st Disease

Rubeola virus (Measles)

Genus of HBoV

Bocavirus

causes a variety of upper and lower respiratory tract illness

Human Bocavirus

Causes warts, tumors, and condylomas in man

Papillomaviridae

HPV causes

Condyloma acuminate

Most common STD

HPV

Very common and typically asymptomatic in most human populations studied

Polyomaviridae

Genus of Polyomavirus except Merkell Cell Virus

Polyomavirus *Merkell - Orthopolyomavirus

First isolated in urine of immunosuppressed kidney tissue transplant patient Named after initials of a Sudanese patient

BK Virus / HPV 1

First isolated from patient with progressive multifocal encephalopathy Causes disease in AIDS px

JC Virus / John Cunningham virus / HPV 2

Discovered in 2007 in samples of human respiratory secretions

KI Virus / HPV 4 WU Virus / HPV 5

KI virus is named after

Karolinska Institute

WU Virus is named after

Washington University

One of the 7 human oncoviruses

Merkell Cell Virus

# of polyomavirus strains

Double stranded linear DNA

Adenoviridae

Number of adenoviridae serotypes

Genus of Adenovirus

Mastadenovirus

Causes common cold and URT diseases like pharyngitis, conjunctivitis, and pneumonia cancer in animals

Adenovirus

Single stranded DNA positive sense Newly discovered genus

Anelloviridae

Ring / circular genome

Anelloviridae

Genus of TTV

Alphatorquevirus

Reported in Japanese patient in 1997

TTV

T or F: Transfusion Transmitted virus is extremely common even in healthy individuals

Other name for Transfusion Transmitted Virus

Torque Teno Virus