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MT6322 > [LEC] Unit 8: DNA Viruses > Flashcards

[LEC] Unit 8: DNA Viruses Flashcards

1
Q

DNA Enveloped Virus

A

Hepadnaviridae
Herpesviridae
Poxviridae

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2
Q

DNA Naked Virus

A

Parvoviridae
Papillomaviridae
Polyomaviridae
Adenoviridae
Anelloviridae

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3
Q

Genus of Hepatitis B virus

A

Orthohepadnavirus

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4
Q

Virion of Hepa B

A

DANE Particle

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5
Q

T or F: Hepadnaviridae is under the classification of double stranded DNA with single stranded region

A

T

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6
Q

Australian Antigen

A

HBsAg

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7
Q

Only marker not found in the serum, only in liver biopsy

A

HBcAg

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8
Q

Components of the core antigen

A

HBeAg

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9
Q

6 HBV serological markers

A

HBsAg
Anti-HBs
Anti-HBc IgM
Anti-HBc
HBeAg
Anti-HBe

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10
Q

T or F: If you are positive in Anti-HBsAg, it means that you
have a current/present or chronic infection

A

F

HBsAg

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11
Q

This HBV marker indicates recovery or immunity; gained after vaccination

A

Anti-HBs

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12
Q

HBV marker present in acute infection (<6 months)

A

Anti-HBc IgM

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13
Q

This HBV marker indicates previous or ongoing infection

A

Anti-HBc

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14
Q

Best HBV marker during the window period

A

HBcAg

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15
Q

This marker indicates that the virus is replicating ir is in high levels

A

HBeAg

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16
Q

This HBV marker indicates indicates lower level of HBV

A

Anti-HBe

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17
Q

T or F: Herpesviridae is double stranded

A

T

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18
Q

Causes lytic and latent infections

A

Herpesviridae

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19
Q

Herpesviridae remain in

A

WBC and peripheral nerves

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20
Q

Genus of HSV 1 and HSV 2

A

Simplexvirus

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21
Q

Diseases caused by Herpes-Simplex Virus 1

A

Oral Herpes – Gingivostomatitis
HSV Encephalitis (Adult)
Ocular Herpes – Keratoconjunctivitis

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22
Q

Diseases caused by Herpes-Simplex Virus 2

A

Genital Herpes
Neonatal Herpes
HSV Encephalitis (Neonates)

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23
Q

T or F: Chickenpox is under HHV3

A

T

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24
Q

Genus of VZV

A

Varicellovirus

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25
Q

Recurrent form of chickenpox

A

Shingles

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26
Q

Large, rounded keratinocyte with a hypertrophic nucleus, hazy or absent nucleoli, and abundant basophilic cytoplasm; associated with chickenpox

A

Tzanck Smear

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27
Q

Genus of EBV

A

Lymphocryptovirus

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28
Q

Disease caused by EBV

A

Infectious Mononucleosis (Kissing disease)

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29
Q

T or F: EBV produces tumors

A

T

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30
Q

Associated with Burkitt’s Lymphoma and other B-cell Lymphoma

A

Epstein-Barr Virus

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31
Q

Primary targets of EBV

A

B Lymphocytes / B cells

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32
Q

Receptor of the virus on the B cell

A

CD21

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33
Q

Lab. diagnoses for EBV

A

Hematology and Immunology

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34
Q

In a hematology di erential smear for EBV, we can detect the
presence of

A

Atypical lymphocytes

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35
Q

nonspecific antibodies; screening test

A

Heterophile Antibody test

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36
Q

confirmatory test for EBV

A

EBV Specific Antibody Test

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37
Q

Test wherein:

IgG positive means you’ve had or currently have the infection; IgM positive means the infection has been reactivated.

A

EBV-VCA IgG/IgM (viral capsid antigen)

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38
Q

EBV test wherein a positive test result is usually associated with past infection.

A

EBV-EBNA IgG (nuclear antigen)

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39
Q

EBV test wherein a positive test may mean you have an active or reactivated infection

A

EBV-EA-D IgG (early antigen)

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40
Q

EBV Specific Antibody Test (5)

A

Anti-VCA
Anti-EA IgG
Anti-EA/D
Anti-EA/R
Anti-EBNA

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41
Q

Formerly “Salivary gland” virus

A

Cytomegalovirus

42
Q

Similar to mononucleosis (In terms of pathology)

A

Cytomegalovirus

43
Q

Cytomegalovirus remains latent in

A

WBC
endothelial cells

44
Q

Microscopic characteristic of Cytomegalovirus

A

Owl’s eye appearance

45
Q

T or F: Most children demonstrate antibody against cytomegalovirus

A

F

Adults

46
Q

Genus of HHV 6 and 7

A

Roseolovirus

47
Q

Diseases caused by HHV 6

A

Exanthem subitum/ Roseola infantum/ 6th disease

48
Q

Cells targeted by HHV 6

A

T cells

49
Q

The most common cause of rashes in children

A

German measles (Rubella)

50
Q

Genus of HHV 8

A

Rhadinovirus

51
Q

Disease caused by HHV 8

A

Kaposi sarcoma

52
Q

T or F: As a double stranded DNA virus, Poxviridae replicates in the nucleus

A

F

cytoplasm

53
Q

Largest and most complex virus
brick or ovoid in shape

A

Poxviridae

54
Q

T or F: Poxviridae produces skin lesions

A

T

55
Q

Orthopox is the genus for

A

Variola
Vaccinia
Cowpox virus
Monkeypox virus

56
Q

Smallpox is caused by

A

Variola

57
Q

First virus to be eradicated

A

Smallpox

58
Q

T or F: Vaccinia virus is pathogenic to man

A

F

59
Q

He developed the vaccine for the Variola virus using the Vaccinia virus/antigen, leading to the eradication of smallpox.

A

Edward Jenner

60
Q

Edward Jenner used the principle of

A

cross-reactivity

61
Q

Genus of Molluscum contagiosum virus

A

Molluscipoxvirus

62
Q

Small pink warts (benign tumors in skin) are caused by

A

Molluscum Contagiosum

63
Q

T or F: Molluscum contagiosum is transmitted via fomites

A

T

64
Q

Zoonotic infection among cows

A

Cowpox virus

65
Q

Prevalent in small communities in Europe

A

Cowpox virus

66
Q

Zoonotic infection (monkeys, rodents)

A

Monkeypox virus

67
Q

Monkeypox virus caused small outbreak in US (2003) – ______ rats from pet store

A

Gambian

68
Q

Genus of ORF virus

A

Parapoxvirus

69
Q

Zoonotic infection (goats, sheep)

A

ORF Virus

70
Q

Caused by ORF

A

contagiosum pustular dermatitis

71
Q

Single stranded linear DNA

A

Parvoviridae

72
Q

2 types of parvoviridae

A

defective and non-defective

73
Q

T or F: In the defective type of parvoviridae, there is a problem with the virus, which requires another virus for replication.

A

T

74
Q

Disease caused by B19 virus

A

Erythema infectiosum (5th disease) or 5th disease

75
Q

T or F: B19 virus was the only member of Polyomaviridae until 2005

A

F

Parvoviridae

76
Q

Causative agent of 1st Disease

A

Rubeola virus (Measles)

77
Q

Genus of HBoV

A

Bocavirus

78
Q

causes a variety of upper and lower respiratory tract illness

A

Human Bocavirus

79
Q

Causes warts, tumors, and condylomas in man

A

Papillomaviridae

80
Q

HPV causes

A

Condyloma acuminate

81
Q

Most common STD

A

HPV

82
Q

Very common and typically asymptomatic in most human populations studied

A

Polyomaviridae

83
Q

Genus of Polyomavirus except Merkell Cell Virus

A

Polyomavirus

*Merkell - Orthopolyomavirus

84
Q

First isolated in urine of immunosuppressed kidney
tissue transplant patient
Named after initials of a Sudanese patient

A

BK Virus / HPV 1

85
Q

First isolated from patient with progressive
multifocal encephalopathy

Causes disease in AIDS px

A

JC Virus / John Cunningham virus / HPV 2

86
Q

Discovered in 2007 in samples of human respiratory secretions

A

KI Virus / HPV 4
WU Virus / HPV 5

87
Q

KI virus is named after

A

Karolinska Institute

88
Q

WU Virus is named after

A

Washington University

89
Q

One of the 7 human oncoviruses

A

Merkell Cell Virus

90
Q

of polyomavirus strains

A

14

91
Q

Double stranded linear DNA

A

Adenoviridae

92
Q

Number of adenoviridae serotypes

A

51

93
Q

Genus of Adenovirus

A

Mastadenovirus

94
Q

Causes common cold and URT diseases like pharyngitis, conjunctivitis, and pneumonia

cancer in animals

A

Adenovirus

95
Q

Single stranded DNA positive sense
Newly discovered genus

A

Anelloviridae

96
Q

Ring / circular genome

A

Anelloviridae

97
Q

Genus of TTV

A

Alphatorquevirus

98
Q

Reported in Japanese patient in 1997

A

TTV

99
Q

T or F: Transfusion Transmitted virus is extremely common even in healthy individuals

A

T

100
Q

Other name for Transfusion Transmitted Virus

A

Torque Teno Virus

MT6322 (4 decks)

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