Lec 80 Schizophrenia Flashcards
What are the positive symptoms of schizophrenia?
hallucinations
delusions
disorganized speech
disorganized behavior
What are negative symptoms of schizophrenia?
- alogia [lack of speech or speech content]
- affective blunting [impaired emotional expression + feeling]
- avolition [lack of energy/drive]
- anhedonia
What are cognitive symptoms of schizophrenia?
impairements in:
- memory
- attention, verbal fluency
What is diagnostic criteria for schizophrenia?
- 2 or more of the following:
- – delusions,
- – hallucinations
- – disorganized speech
- – disorganize or catatonic behavior
- – negative symptoms [flat affect, social withdrawal, lack of motivation/speech/through]
- social occupation/dysfunction
- duration > 6 mos
What differentiates brief psychotic disorder vs schisophreniform disorder vs schizophrenia?
brief psychotic disorder = < 1 mo –> usually stress related
schizophreniform disorder = 1-6
schizophrenia = > 6 mo
What is schizoaffective disorder?
schizophrenia + mood disorder
at least 2 wks of stable mood with psychotic symptoms PLUS major depressive, manic, or mixed episode
2 types = bipolar or depressive
How do you differentiate schizophrenia from schizoaffective disorder and depressive or bipolar disorder with psychotic features?
schizophrenia has:
- no major depressive or manic episodes concurrently with active-phase symptoms
- if mood episodes occurred during active symptoms –> present for a minority of total duration of active and residual periods of the illness
What is lifetime prevalence of schizophrenia?
- 5%
- males = females; blacks = whites
- presents earlier in men [late teens - 20s]; later in women [late 20s - 30s]
How does delusional disorder differ from schizophrenia?
non-bizarre delusions in delusional disorder
What is premorbid state of schizophrenia?
- time before prodrome/onset begins
- affected individuals have good functioning but may have subtle cognitive problems [missed development milestone, reduced IQ, etc]
What is prodrome phase of schizophrenia?
- period during which individuals have social withdrawal and decline in function, inappropriate affect, work-school impairment, strange ideation, deterioration in hygiene
- lasts mos - yrs
What is active/progressive phase of schizophrenia?
psychotic symptoms appear
have exacerbations and remissions
have progression/decline in functioning
What is chronic/ residual phase of schizophrenia?
absent/attenuated positive symptoms but continued negative symptoms
cognitive impairment
acute exacerbations
What is risk of suicide in schizophrenia?
20-50% of pts have suicidal ideation or attempt
higher in males and comorbid depression/alc use
What medical co=morbidities with schizophrenia?
- 20% reduction in lifespan
- increase suicide/accidents
- increased alcohol, substance abuse, smoking
- excess CV mortality [sedentary life style, obesity, metabolic syndrome]
