Lec 75 Mood stabilizers

Question 1

What is a mood stabilizer?

Answer 1

• intervention effective in treating acute mania and depression

Question 2

What phases of illness can mood stabilizers treat?

Answer 2

• acute depression
• acute mania
• acute mixed state
• maintenance [prevention depression and mania]

Question 3

What are pharmacokinetics of lithium?

Answer 3

• GI absorption
• not protein bound
• not metabolized
• filtered at glomerulus and reabsorbed by prox tubule
• excreted in urine
• 1/2 life 20-24 hrs [reaches stead state plasma level 4-5 days]

Question 4

Which drugs affect lithium excretion?

Answer 4

increase excretion: carb anhydrase inhibitors, osmotic diuretics

decrease excretion: lasix, NSAIDS, tetracycline, cyclosporine, ACE inhibitors

Question 5

What are side effects of lithium?

Answer 5

LMNOP
lithium –> movement [tremor], Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems

• effect on tubular function, glomerulus, lithium induced nephropathy

Question 6

How do you treat lithium tox?

Answer 6

stop drug, give IV hydration

may need dialysis

Question 7

What is goal blood level for lithium?

Answer 7

blood level = 0.6-1.2 mEq/L for mania; 0.4-0.8 for augmentation

check level + renal + thyroid function every 6-12 mo