Lec 8 tissue architecture

Question 1

cytoskeleton filaments types

Answer 1

intermediate filaments, microtubules, microfilaments

Question 2

Intermediate filaments

Answer 2

great tensile strength forms a network throughout cytoplasm Does nuclear lamina

Question 3

Nuclear lamina

Answer 3

underlies and supports nuclear envelope

Question 4

microtubules

Answer 4

organizational role. hollow tubules create tracks for transport of vesicles, organelles, and other cell component. mitotic spindle.

Question 5

gamma tubules role in microtubules

Answer 5

anchoring points for microtubules to attach to

Question 6

Drugs that affect microtubules

Answer 6

Question 7

Microfilaments (role)

Answer 7

actin filaments

many unstable by self (will bind to be stable)

essential for cell movement

Question 8

drugs that affect microfilaments

Answer 8

Question 9

extracellular matrix and basal lamina

Answer 9

produced intercellularly and secreted and aggregate

interacts with cells/tissues via transmembrane proteins

many different functions by location/tissue type

Question 10

Collagen. (what is it part of and what is it?)

Answer 10

main structural part of extracellular matrix/basal lamina

trimeric

many different types and function by location

RER starts in making

Question 11

Scurvy

Answer 11

collagen break down (lysl hydroxalases)

structures dont hold together

Question 12

Ehlers Danlos syndrome

Answer 12

weakens connective tissue due to mutation in collagen or collagen synthesis gene

Question 13

Cell adhesion molecules (CAM)

Answer 13

3 domains

extracellular -binding to adjacent cell/matrix proteins

transmembrane- links CAM to membrane

cytoplasmic- bind to cytoskeleton using linker proteins

Question 14

4 major families of CAM

Answer 14

1. Cadherins
2. Ig-superfamily
3. integrin
4. selectin

Question 15

Cadherin superfamily

Answer 15

Ca2+ dependent (important in forming junctions in cell)

E-epithelial

N- neural

VE- vascular

LI- liver

Question 16

Cadherin and tumors

Answer 16

Question 17

Ig superfamily CAMs

Answer 17

calcium independent

immune cell interactions

involved in recognition, binding, adhesion processes of cells

Question 18

selectins

Answer 18

Ca2+ dependent

bind to extracellular carbs

important in host defense mechanisms

(inflammatory response)

Question 19

selectin and WBC

Answer 19

WBC have carbs on the outside

low affinity for ligand allows for leukocyte rolling during cascade

Question 20

Integrins

Answer 20

couple extracellular matrix to cell cytoskeleton

activate signalling pathways

cell-cell interaction via b-2

integrins on leukocytes allow adhesion and transmigration to infected area