Lec 8 tissue architecture Flashcards
cytoskeleton filaments types
intermediate filaments, microtubules, microfilaments
Intermediate filaments
great tensile strength forms a network throughout cytoplasm Does nuclear lamina
Nuclear lamina
underlies and supports nuclear envelope
microtubules
organizational role. hollow tubules create tracks for transport of vesicles, organelles, and other cell component. mitotic spindle.
gamma tubules role in microtubules
anchoring points for microtubules to attach to
Drugs that affect microtubules
Microfilaments (role)
actin filaments
many unstable by self (will bind to be stable)
essential for cell movement
drugs that affect microfilaments
extracellular matrix and basal lamina
produced intercellularly and secreted and aggregate
interacts with cells/tissues via transmembrane proteins
many different functions by location/tissue type
Collagen. (what is it part of and what is it?)
main structural part of extracellular matrix/basal lamina
trimeric
many different types and function by location
RER starts in making
Scurvy
collagen break down (lysl hydroxalases)
structures dont hold together
Ehlers Danlos syndrome
weakens connective tissue due to mutation in collagen or collagen synthesis gene
Cell adhesion molecules (CAM)
3 domains
extracellular -binding to adjacent cell/matrix proteins
transmembrane- links CAM to membrane
cytoplasmic- bind to cytoskeleton using linker proteins
4 major families of CAM
- Cadherins
- Ig-superfamily
- integrin
- selectin
Cadherin superfamily
Ca2+ dependent (important in forming junctions in cell)
E-epithelial
N- neural
VE- vascular
LI- liver
Cadherin and tumors
Ig superfamily CAMs
calcium independent
immune cell interactions
involved in recognition, binding, adhesion processes of cells
selectins
Ca2+ dependent
bind to extracellular carbs
important in host defense mechanisms
(inflammatory response)
selectin and WBC
WBC have carbs on the outside
low affinity for ligand allows for leukocyte rolling during cascade
Integrins
couple extracellular matrix to cell cytoskeleton
activate signalling pathways
cell-cell interaction via b-2
integrins on leukocytes allow adhesion and transmigration to infected area
