Lec 7 Basic Blood

Question 1

Serum vs plasma

Answer 1

serum is plasma without clotting factors

Question 2

Albumin importance

Answer 2

50% of proteins in plasma (made in liver). major source of colloid osmotic pressure

Question 3

Globulins

Answer 3

immunoglobulins- like antibodies nonimmunglobulins- osmotic pressure, coag factors

Question 4

Fibrinogen

Answer 4

largest protein (made liver) soluble. fibrin block clots insoluble

Question 5

Erythrocytes

Answer 5

Question 6

What is a reticulocyte?

Answer 6

An immature rbc hasn’t shed the organelles. mature in 1-2 days

Question 7

Integral membrane proteins in erythrocytes

Answer 7

Glycophorin C

Band 3 proteins

Question 8

Glycophorin c function

Answer 8

attaches underlying cytoskeleton network to cell membrane (interacts with band 4.1 protein complex)

Question 9

Band 3 protein function

Answer 9

binds hemoglobin. and acts as anchoring site for cytoskeleton proteins

(interacts with ankyrin protein complex)

Question 10

What are long heterodimers that form long flexible tetramers creating latice?

Answer 10

alpha and beta spectrin molecules

Question 11

anemia

Answer 11

Question 12

The types of cytoskeleton defects

Answer 12

spherocytosis

elliptocytosis

Question 13

spherocytosis

Answer 13

autosomal dominant

ankyrin complex faulty

membrane detach and peel off

goes spherical

Question 14

elliptocytosis

Answer 14

Autosomal dominant

spectrin to spectrin faulty

ankyrin to band 4.1 junctions faulty

cells dont rebound and then elongate

Question 15

Jaundice

Answer 15

can be caused by destroying erythrocytes

Question 16

sickle cell

Answer 16

rbc more fragile die over 20 days instead of 120

Question 17

Leukocytes different types and mnemonics

Answer 17

Granulocytes- (all the phils). neutrophil, eosinophil, basophil

Agranulocytes- lymphocytes and monocytes

by abundance (Never Let Monkeys Eat Bananas)

Question 18

Neutrophils (staining and function)

Answer 18

Question 19

Types of neutrophil granules

Answer 19

Question 20

eosinophils staining and function

Answer 20

Pink stain

Question 21

Basophils (function and staining)

Answer 21

Question 22

Lymphocytes (function and staining)

Answer 22

Question 23

lymphocytes can become what?

Answer 23

B-cells

T-cells

natural killer cells

B/T cells indistinguishable on stain

Question 24

Monocytes (function and staining)

Answer 24

Question 25

Thrombocytes (function and where they come from)

Answer 25

Question 26

thrombocytosis (what happens)

Answer 26