Lec 7 Basic Blood Flashcards
Serum vs plasma
serum is plasma without clotting factors
Albumin importance
50% of proteins in plasma (made in liver). major source of colloid osmotic pressure
Globulins
immunoglobulins- like antibodies nonimmunglobulins- osmotic pressure, coag factors
Fibrinogen
largest protein (made liver) soluble. fibrin block clots insoluble
Erythrocytes
What is a reticulocyte?
An immature rbc hasn’t shed the organelles. mature in 1-2 days
Integral membrane proteins in erythrocytes
Glycophorin C
Band 3 proteins
Glycophorin c function
attaches underlying cytoskeleton network to cell membrane (interacts with band 4.1 protein complex)
Band 3 protein function
binds hemoglobin. and acts as anchoring site for cytoskeleton proteins
(interacts with ankyrin protein complex)
What are long heterodimers that form long flexible tetramers creating latice?
alpha and beta spectrin molecules
anemia
The types of cytoskeleton defects
spherocytosis
elliptocytosis
spherocytosis
autosomal dominant
ankyrin complex faulty
membrane detach and peel off
goes spherical
elliptocytosis
Autosomal dominant
spectrin to spectrin faulty
ankyrin to band 4.1 junctions faulty
cells dont rebound and then elongate
Jaundice
can be caused by destroying erythrocytes
sickle cell
rbc more fragile die over 20 days instead of 120
Leukocytes different types and mnemonics
Granulocytes- (all the phils). neutrophil, eosinophil, basophil
Agranulocytes- lymphocytes and monocytes
by abundance (Never Let Monkeys Eat Bananas)
Neutrophils (staining and function)
Types of neutrophil granules
eosinophils staining and function
Pink stain
Basophils (function and staining)
Lymphocytes (function and staining)
lymphocytes can become what?
B-cells
T-cells
natural killer cells
B/T cells indistinguishable on stain
Monocytes (function and staining)
Thrombocytes (function and where they come from)
thrombocytosis (what happens)
