lec 2 DD Flashcards
What is a drug delivery system?
A formulation or device that enables the transport of drugs in the body, improving efficacy and safety.
Definition by Kewal K. Jain, 2014.
List the ideal characteristics of a drug delivery system.
- Biocompatible
- Increases bioavailability
- Provides controlled drug delivery
- Targets site of action while avoiding non-diseased tissues
- Stable
- Maintains delivery under varying conditions
- Applicable to a wide range of drugs
- Easy to administer
- Safe and reliable
- Cost-effective
What are the primarily used routes of drug administration?
Oral and parenteral delivery.
What are fast dissolving tablets designed to overcome?
The problem of swallowing conventional tablets, especially in geriatric and pediatric patients.
Name examples of super disintegrants.
- Crospovidone
- Croscarmellose sodium
- Sodium starch glycolate
- Soy polysaccharides
- Chitin
- Chitosan
What are floating systems in drug delivery?
Low-density formulations that remain buoyant on stomach contents, allowing for prolonged gastric residence time.
Describe high-density systems in drug delivery.
Dense formulations that sink to the bottom of the stomach, useful for targeted delivery to the gastric region.
What are mucoadhesive systems?
Formulations containing polymers designed to adhere to the mucosal lining.
What are the types of drug delivery based on release and availability?
- Systemic vs localized drug delivery
- General non-targeted delivery
- Targeted delivery to a specific organ
- Immediate release
- Programmed release
- Delayed, sustained, or prolonged release
What characterizes programmed release or pulsatile release?
A time period of no release followed by rapid or complete drug release, which can be time-controlled, stimuli-induced, or externally regulated.
What is the ‘PORT’ System?
A capsule coated with a semipermeable membrane containing an insoluble plug and drug formulation that allows for controlled release after a lag time.
What are the limitations of sustained release drug delivery systems?
- Increased drug costs
- Variation in drug-level profile with food intake
- Chemical modifications altering distribution and pharmacokinetics
What is the significance of distinguishing between the drug and the device in drug delivery systems?
It is important for regulatory control.
What is reservoir-based drug delivery?
A controlled drug delivery system where drug release is controlled by polymer properties and drug characteristics.
What are biodegradable implants?
Implants that degrade under biological conditions to non-toxic products eliminated from the body.
What is the purpose of infusion pumps in drug delivery?
To provide external control of delivery rate and volume, allowing for continuous therapy.
What are intrauterine implants used for?
Contraceptive devices that can be long-acting and reversible.
Fill in the blank: A drug delivery system should be _______ and reliable.
safe
True or False: Fast dissolving tablets use conventional disintegrants.
False
