Lec 1 Flashcards
qualifications for FULL IRB review
- more than minimal risk
- sensitive topic
- minors or other vulnerable populations (prisoners, fetus)
most prospective research that includes an intervention requires a ____ IRB review
full
qualifications for expedited IRB review
- minimal risk
- blood draw < 5 mL, physical exam, routine psychological testing
- non-interventional studies (observation)
- survey/questionnaire (non-sensitive)
- electrophysiological studies
- genomic studies
- non-invasive imaging
- collecting or meta-analysis of existing data
T/F: a survey/questionnaire has to be anonymous to qualify for expedited review
F
qualifications for exempt IRB review
- little to no risk
- no sensitive topic
- no vulnerable populations
examples of IRB exempt research
- anonymous questionnaires
- educational setting with normal curriculum
- archival data with anonymous data
EBP is the integration of
EQUALLY:
best research evidence
clinical expertise
patient values
what does FINER stand for when considering a research study?
Feasible
Interesting
Novel
Ethical
Relevant
what is the difference between Medline and PubMed?
PubMed is just a means to access Medline; Medline is an actual database
what are secondary sources of information?
books
meta-analyses
reviews
systematic reviews
what are primary sources of information?
clinical trials
randomized control trials
what are the strengths of primary source articles?
- immediately current
- many available online in full text
what are the weaknesses of primary source articles?
- must read and extract info (expt PEDro)
- only find articles in journals listed in their engine
what are the grades of the strength of evidence? strongest? weakest?
A-F
A = strongest
F = weakest
what is the order of evidence strength by levels from strongest to weakest?
1a
1b
1c
2a
2b
2c
3a
3b
4
5
what is a 1a?
systematic reviews of RCTs
what is a 1b?
RCT with narrow CI
what is a 1c?
all or none
what is a 2a?
systematic review of cohort studies
what is a 2b?
cohort study or low quality RCT
what is a 2c?
outcomes research
what is a 3a?
systemic review of case-control studies
what is a 3b?
individual case-control studies
what is a 4?
case reports, small case studies
